TRIP6 and SIK3

Number of citations of the paper that reports this interaction (PubMedID 21516116)
94

Data Source:
BioGRID (two hybrid)

		TRIP6	SIK3
Description		thyroid hormone receptor interactor 6	SIK family kinase 3
Image			No pdb structure
GO Annotations	Cellular Component	Stress Fiber Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion	Cytoplasm
	Molecular Function	RNA Binding Interleukin-1 Receptor Binding Protein Binding Kinase Binding Metal Ion Binding Thyroid Hormone Receptor Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Tau-protein Kinase Activity
	Biological Process	Signal Transduction Positive Regulation Of Cell Migration Chordate Embryonic Development Focal Adhesion Assembly Positive Regulation Of NIK/NF-kappaB Signaling	Microtubule Cytoskeleton Organization Protein Phosphorylation Intracellular Signal Transduction Positive Regulation Of TORC1 Signaling Positive Regulation Of TORC2 Signaling
Pathways
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Heart rate increase in response to exercise ( 29497042) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Nonunion in individuals with fractures ( 30680360) Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020)	Allergic rhinitis ( 30013184) Blood protein levels ( 28240269) Delirium ( 29631748) Eosinophil counts ( 27863252) Eosinophil percentage of white cells ( 27863252) HDL cholesterol ( 31170924 24886709) Hearing function ( 25060954) Medication use (thyroid preparations) ( 31015401) Metabolic syndrome ( 30382898) Non-accommodative esotropia ( 30098192) Response to Vitamin E supplementation ( 22437554) Sum eosinophil basophil counts ( 27863252) Triglyceride levels ( 29615537) Triglycerides ( 24886709)
Interacting Genes		112 interacting genes: ABI2 ADAMTSL4 AQP1 ARNT2 ATN1 ATP23 ATP5PO ATXN1 AXIN1 BCAR1 BYSL CATSPER1 CBLC CCL5 CEP57L1 CNTF CREB5 CRYBA4 CTAG2 DHX37 DMRT3 DTX2 EFHC1 EXOC3-AS1 FAM124B FASLG FHL3 FRS3 GAD1 GATA1 GDPD5 GFI1B GNAI2 GSE1 HLA-DPB1 HOXA1 HOXA9 HOXB9 HYKK IL16 ILF3 INCA1 IQCN KIF1A KIR2DL4 KLK15 KRTAP26-1 LMO2 LPAR2 MAPKBP1 MEMO1 METTL17 MSRB3 MVP NCK2 NEDD9 NEU4 NOL4L-DT NUP210 ODF1 OIP5 OTUB2 PDGFRB PDLIM4 PIN1 POM121 POM121L4P PPP1R16A PRKAA1 PRKAA2 PTK2 PTPN13 PXN RAD23A RERE RFX3 RHOA RHOQ RNF213 RNF214 SAXO1 SCRIB SIK3 SLC15A3 SLC25A6 SMAD1 SON SRC STAC STK16 SVIL SYNGAP1 TAB1 TCAF1 TEKT4 TENT5C THRB TLR2 TMSB4X TPM3 TPM4 TRAF3IP2 TRAPPC2L TRIM29 TTLL10 TXN2 TXNDC5 VCL WT1-AS YPEL3 ZBP1 ZNF688	7 interacting genes: ATP5MG CRTC2 HDAC5 PRKACA TRAF1 TRIP6 YWHAZ
Entrez ID		7205	23387
HPRD ID		04242	11121
Ensembl ID		ENSG00000087077	ENSG00000160584
Uniprot IDs		Q15654	A1A5A9 Q9Y2K2
PDB IDs		1X61 2DLO
Enriched GO Terms of Interacting Partners?
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