ITGB6 and FHL2

Number of citations of the paper that reports this interaction (PubMedID 10906324)
29

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, two hybrid)

		ITGB6	FHL2
Description		integrin subunit beta 6	four and a half LIM domains 2
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GO Annotations	Cellular Component	Nucleoplasm Centrosome Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Cell Junction Integrin Alphav-beta6 Complex Receptor Complex	Nucleus Nucleoplasm Focal Adhesion Z Disc M Band
	Molecular Function	Virus Receptor Activity Integrin Binding Protein Binding Signaling Receptor Activity	Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Identical Protein Binding Metal Ion Binding Androgen Receptor Binding
	Biological Process	Inflammatory Response Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Cell Migration Extracellular Matrix Organization Cell Adhesion Mediated By Integrin Transforming Growth Factor-beta Secretion Viral Entry Into Host Cell Regulation Of Transforming Growth Factor Beta Activation	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Response To Hormone Regulation Of Lipid Metabolic Process Androgen Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Atrial Cardiac Muscle Cell Development Ventricular Cardiac Muscle Cell Development Heart Trabecula Formation Negative Regulation Of Calcineurin-NFAT Signaling Cascade
Pathways		Elastic fibre formation Molecules associated with elastic fibres Integrin cell surface interactions ECM proteoglycans	PPARA activates gene expression
Drugs
Diseases
GWAS		Asthma (childhood onset) ( 31036433) Idiopathic membranous nephropathy ( 21323541) Tourette syndrome ( 30818990) Type 2 diabetes ( 20418489) Waist circumference adjusted for body mass index ( 25673412)	Body fat mass ( 28552196) Household income (MTAG) ( 31844048) Lung cancer in ever smokers ( 28604730) Pulse pressure ( 30224653 30578418)
Interacting Genes		8 interacting genes: FHL2 FLNA FLNB FN1 ITGAV MAPK1 TGFB1 VTN	98 interacting genes: ADAM17 AK1 APP AR ARHGAP9 ATXN1 BANP BIN1 BLZF1 BMPR2 BRCA1 CAPN1 CARD8 CCDC92 CKM CREBBP CSK CSN2 CTNNB1 DCP1A DPF2 DTX2 DUSP10 E2F1 E2F2 E2F3 E2F4 EP300 ESR1 FHL1 FHL3 FHL5 FOXO1 GLYR1 GNG12 HAND1 HCK HSPB2 ID3 IDH1 IER3 IGFBP5 IKZF4 INCA1 ITGA3 ITGA7 ITGB1 ITGB2 ITGB5 ITGB6 JUP KANK2 KIAA1217 MCM7 MDM2 MYBPC1 NIBAN1 NRF1 PFKM PHB2 PSEN2 PUF60 RAI2 REL REV1 RFX3 RUNX2 SAP30BP SAXO1 SFPQ SIGLEC6 SLC34A1 SMAD2 SMAD3 SMAD4 SP2 SRF STAT3 SUMO1P1 TNFRSF11A TRAF6 TRIM55 TRIM63 TTN WT1 ZBTB16 ZBTB25 ZFP64 ZFYVE9 ZMYM4 ZNF131 ZNF212 ZNF3 ZNF331 ZNF408 ZNF417 ZNF626 ZNF638
Entrez ID		3694	2274
HPRD ID		00947	04026
Ensembl ID		ENSG00000115221	ENSG00000115641
Uniprot IDs		A0A087WXP3 B4E2B8 E9PEE8 P18564	Q14192 Q2XQU9 Q6I9R8
PDB IDs		1LH9 4UM8 4UM9 5FFG 5FFO 5NEM 5NER 5NET 5NEU	1X4K 1X4L 2D8Z 2MIU
Enriched GO Terms of Interacting Partners?
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