FHL2 and STAT3

Number of citations of the paper that reports this interaction (PubMedID 18255255)
8

Data Source:
BioGRID (two hybrid)

		FHL2	STAT3
Description		four and a half LIM domains 2	signal transducer and activator of transcription 3
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Focal Adhesion Z Disc M Band	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Mitochondrial Inner Membrane Cytosol Plasma Membrane Postsynaptic Density RNA Polymerase II Transcription Factor Complex Schaffer Collateral - CA1 Synapse Glutamatergic Synapse
	Molecular Function	Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Identical Protein Binding Metal Ion Binding Androgen Receptor Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Repressing Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Transcription Factor Binding Protein Kinase Binding Protein Phosphatase Binding Chromatin DNA Binding CCR5 Chemokine Receptor Binding Glucocorticoid Receptor Binding Identical Protein Binding Protein Homodimerization Activity Transcription Regulatory Region DNA Binding Protein Dimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Response To Hormone Regulation Of Lipid Metabolic Process Androgen Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Atrial Cardiac Muscle Cell Development Ventricular Cardiac Muscle Cell Development Heart Trabecula Formation Negative Regulation Of Calcineurin-NFAT Signaling Cascade	Negative Regulation Of Transcription By RNA Polymerase II Temperature Homeostasis Eye Photoreceptor Cell Differentiation Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Protein Import Into Nucleus Defense Response Acute-phase Response Inflammatory Response Signal Transduction JAK-STAT Cascade Nervous System Development Aging Cell Proliferation Negative Regulation Of Cell Proliferation Negative Regulation Of Autophagy Positive Regulation Of Gene Expression Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Viral Process Phosphorylation Cytokine-mediated Signaling Pathway Sexual Reproduction Positive Regulation Of Cell Migration Intracellular Receptor Signaling Pathway Response To Estradiol Cellular Response To Hormone Stimulus Leptin-mediated Signaling Pathway Somatic Stem Cell Population Maintenance MiRNA Mediated Inhibition Of Translation Interleukin-15-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Interleukin-9-mediated Signaling Pathway Interleukin-21-mediated Signaling Pathway Interleukin-23-mediated Signaling Pathway Regulation Of Multicellular Organism Growth Regulation Of Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Glucose Homeostasis Eating Behavior MRNA Transcription By RNA Polymerase II Response To Peptide Hormone Cellular Response To Leptin Stimulus Response To Leptin Positive Regulation Of Interleukin-6 Biosynthetic Process Response To Ethanol Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Angiogenesis Negative Regulation Of Glycolytic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Mitochondrial Membrane Permeability Astrocyte Differentiation Modulation Of Chemical Synaptic Transmission Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cell Cycle Radial Glial Cell Differentiation Regulation Of Feeding Behavior Growth Hormone Receptor Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Interleukin-6-mediated Signaling Pathway Interleukin-27-mediated Signaling Pathway Interleukin-35-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Cellular Response To Organic Cyclic Compound T-helper 17 Cell Lineage Commitment Energy Homeostasis Postsynapse To Nucleus Signaling Pathway Negative Regulation Of Neuron Death Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Metalloendopeptidase Activity Positive Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Gene Silencing By MiRNA Negative Regulation Of Stem Cell Differentiation Positive Regulation Of ATP Biosynthetic Process Negative Regulation Of Neuron Migration
Pathways		PPARA activates gene expression	Interleukin-6 signaling BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Interleukin-7 signaling Interleukin-7 signaling Signaling by SCF-KIT Signaling by cytosolic FGFR1 fusion mutants Downstream signal transduction Signalling to STAT3 Senescence-Associated Secretory Phenotype (SASP) Signaling by Leptin POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Association of TriC/CCT with target proteins during biosynthesis Transcriptional regulation of pluripotent stem cells Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling PTK6 Activates STAT3 PTK6 Activates STAT3 Interleukin-20 family signaling MET activates STAT3 MET activates STAT3 Interleukin-15 signaling Interleukin-35 Signalling Interleukin-9 signaling Interleukin-37 signaling Interleukin-23 signaling Interleukin-23 signaling Interleukin-27 signaling Interleukin-21 signaling Transcriptional regulation of granulopoiesis Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants Growth hormone receptor signaling
Drugs
Diseases			Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) Oral cancer
GWAS		Body fat mass ( 28552196) Household income (MTAG) ( 31844048) Lung cancer in ever smokers ( 28604730) Pulse pressure ( 30224653 30578418)	Atopic dermatitis ( 26482879) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Composite immunoglobulin trait (IgA/IgG) ( 28628107) Crohn's disease ( 18587394 28067908 21102463 23266558) Diastolic blood pressure ( 30578418) Inflammatory bowel disease ( 27569725 28067908 26278503 23128233) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mean corpuscular volume ( 27863252) Multiple sclerosis ( 31604244 22190364 24076602 21833088 20159113) Psoriasis ( 25903422 23143594) Systemic lupus erythematosus ( 28714469) Type 2 diabetes ( 30054458) Ulcerative colitis ( 28067908)
Interacting Genes		98 interacting genes: ADAM17 AK1 APP AR ARHGAP9 ATXN1 BANP BIN1 BLZF1 BMPR2 BRCA1 CAPN1 CARD8 CCDC92 CKM CREBBP CSK CSN2 CTNNB1 DCP1A DPF2 DTX2 DUSP10 E2F1 E2F2 E2F3 E2F4 EP300 ESR1 FHL1 FHL3 FHL5 FOXO1 GLYR1 GNG12 HAND1 HCK HSPB2 ID3 IDH1 IER3 IGFBP5 IKZF4 INCA1 ITGA3 ITGA7 ITGB1 ITGB2 ITGB5 ITGB6 JUP KANK2 KIAA1217 MCM7 MDM2 MYBPC1 NIBAN1 NRF1 PFKM PHB2 PSEN2 PUF60 RAI2 REL REV1 RFX3 RUNX2 SAP30BP SAXO1 SFPQ SIGLEC6 SLC34A1 SMAD2 SMAD3 SMAD4 SP2 SRF STAT3 SUMO1P1 TNFRSF11A TRAF6 TRIM55 TRIM63 TTN WT1 ZBTB16 ZBTB25 ZFP64 ZFYVE9 ZMYM4 ZNF131 ZNF212 ZNF3 ZNF331 ZNF408 ZNF417 ZNF626 ZNF638	203 interacting genes: ABL2 ADRB2 AMBP AR ARFIP2 ASXL1 ATF3 BATF3 BCKDK BHLHE40 BICD1 BLK BMX BRCA1 BRWD1 CA8 CAPN1 CAPNS1 CBL CCDC87 CCND1 CCR1 CCR5 CDK9 CDKN1A CEP120 CHTF18 CNDP2 CORO1A CREBBP CSF2RB CSF3R CXCR4 DAXX DOK2 DOK3 DTNA ECH1 EGFR EIF2AK2 ELP2 EP300 EPHA3 ERBB2 ERBIN FAM117B FER FES FGFR3 FGFR4 FGR FHL2 FLT1 FOXM1 FYN GATA1 GATA2 GHR GNL3 GSTCD GTF2I HCK HDAC1 HDAC2 HDAC3 HES1 HES5 HESX1 HIF1A HIVEP1 HLA-A HNF1A HNRNPM HOXC11 HSP90AA1 HSP90AB1 IFNAR1 IFNAR2 IGF1R IL1RAP IL22RA1 IL23R IL2RA IL2RB IL6R IL6ST IL7R IRAK1 JAK1 JAK2 JAK3 JUN KAT5 KDM1A KHDRBS1 KLF15 KPNA1 KPNA6 KRTAP10-7 LAMB2 LASP1 LCK LEPR LMO2 LYN MAP3K13 MAP3K7 MAPK1 MAPK3 MAPK8 MAPKAPK2 MET MNDA MORC4 MPZL1 MRPS31 MTOR MYOD1 NACAD NCOA1 NDUFA13 NFKB1 NFKBIZ NIF3L1 NLK NMI NR3C1 NR4A1 NUFIP2 NXT2 OFCC1 OGDHL PAFAH1B2 PAQR7 PCBD2 PDGFRA PDGFRB PDIA3 PELP1 PIAS3 PIK3R1 PIK3R2 PIK3R3 PINK1 PML PPARD PRKCD PTK2B PTMA PTPN1 PTPN11 PTPN2 RABGAP1 RAC1 RACK1 RB1 RELA RET RPA2 RPL11 RPS6KA5 RPS9 RRAD SCAF11 SETD7 SH2D2A SH3BP2 SIAH2 SIN3A SMARCA4 SPRY1 SRC SRI SRRT SS18L1 STAP2 STAT1 STAT4 STAT5A STAT5B STAT6 STMN1 SULT2A1 SUMO4 SUPT20H SYK TASOR2 TDG TM4SF19 TRIM28 TRIP10 TSHR TSLP TWIST1 VPS39 WDFY3 ZFPM2 ZNF148 ZNF281 ZNF467 ZNF557 ZNF829 ZNRD2
Entrez ID		2274	6774
HPRD ID		04026	00026
Ensembl ID		ENSG00000115641	ENSG00000168610
Uniprot IDs		Q14192 Q2XQU9 Q6I9R8	P40763
PDB IDs		1X4K 1X4L 2D8Z 2MIU	5AX3 5U5S 6QHD
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?