ITGB6 and FLNB

Number of citations of the paper that reports this interaction (PubMedID 11807098)
40

Data Source:
BioGRID (two hybrid)

		ITGB6	FLNB
Description		integrin subunit beta 6	filamin B
Image
GO Annotations	Cellular Component	Nucleoplasm Centrosome Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Cell Junction Integrin Alphav-beta6 Complex Receptor Complex	Stress Fiber Cell Nucleus Cytoplasm Cytosol Plasma Membrane Brush Border Focal Adhesion Cell Cortex Actin Cytoskeleton Integral Component Of Membrane Z Disc Neuron Projection Neuronal Cell Body Phagocytic Vesicle Extracellular Exosome
	Molecular Function	Virus Receptor Activity Integrin Binding Protein Binding Signaling Receptor Activity	RNA Binding Actin Binding Protein Binding Identical Protein Binding Cadherin Binding
	Biological Process	Inflammatory Response Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Cell Migration Extracellular Matrix Organization Cell Adhesion Mediated By Integrin Transforming Growth Factor-beta Secretion Viral Entry Into Host Cell Regulation Of Transforming Growth Factor Beta Activation	Keratinocyte Development Epithelial Cell Morphogenesis Cytoskeletal Anchoring At Plasma Membrane Signal Transduction Skeletal Muscle Tissue Development Actin Cytoskeleton Organization Cellular Response To Interferon-gamma
Pathways		Elastic fibre formation Molecules associated with elastic fibres Integrin cell surface interactions ECM proteoglycans	ISG15 antiviral mechanism
Drugs
Diseases			Spondylocarpotarsal synostosis syndrome FLNB-related disorders, including: ; Atelostogenesis, type I; Boomerang dysplasia; Atelosteogenesis, type III; Larsen syndrome
GWAS		Asthma (childhood onset) ( 31036433) Idiopathic membranous nephropathy ( 21323541) Tourette syndrome ( 30818990) Type 2 diabetes ( 20418489) Waist circumference adjusted for body mass index ( 25673412)	Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) ( 23648065) Eating disorders (purging via substances) ( 23568457) Gut microbiota (bacterial taxa) ( 27723756) Height ( 31217584) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Optic cup area ( 25631615 31798171 28073927) Pulse pressure ( 30578418) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Systemic sclerosis ( 31672989) Vertical cup-disc ratio ( 28073927) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		8 interacting genes: FHL2 FLNA FLNB FN1 ITGAV MAPK1 TGFB1 VTN	20 interacting genes: ASB2 ATF7IP FBLIM1 FLNA GP1BA HSPB1 ITGB1 ITGB3 ITGB6 MLH1 NPHP1 PLEKHO1 PSEN1 PSEN2 PTEN RAD21 SMURF2 TRIM55 TSC22D2 TSHR
Entrez ID		3694	2317
HPRD ID		00947	04543
Ensembl ID		ENSG00000115221	ENSG00000136068
Uniprot IDs		A0A087WXP3 B4E2B8 E9PEE8 P18564	O75369
PDB IDs		1LH9 4UM8 4UM9 5FFG 5FFO 5NEM 5NER 5NET 5NEU	2DI8 2DI9 2DIA 2DIB 2DIC 2DJ4 2DLG 2DMB 2DMC 2E9I 2E9J 2EE6 2EE9 2EEA 2EEB 2EEC 2EED 2WA5 2WA6 2WA7 3FER 4B7L 5DCP
Enriched GO Terms of Interacting Partners?
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