IL6ST and IL6

Number of citations of the paper that reports this interaction (PubMedID 14557255)
2

Data Source:
HPRD (in vivo)

		IL6ST	IL6
Description		interleukin 6 signal transducer	interleukin 6
Image
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Interleukin-6 Receptor Complex Oncostatin-M Receptor Complex External Side Of Plasma Membrane Membrane Dendrite Neuronal Cell Body Receptor Complex Extracellular Exosome Ciliary Neurotrophic Factor Receptor Complex	Extracellular Region Extracellular Space Cell Endoplasmic Reticulum Lumen Interleukin-6 Receptor Complex
	Molecular Function	Cytokine Receptor Activity Ciliary Neurotrophic Factor Receptor Activity Interleukin-6 Receptor Activity Interleukin-11 Receptor Activity Leukemia Inhibitory Factor Receptor Activity Oncostatin-M Receptor Activity Ciliary Neurotrophic Factor Receptor Binding Interleukin-6 Receptor Binding Protein Binding Growth Factor Binding Cytokine Binding Interleukin-11 Binding Interleukin-6 Binding Identical Protein Binding Interleukin-27 Receptor Activity	Cytokine Activity Interleukin-6 Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Positive Regulation Of Acute Inflammatory Response Positive Regulation Of Adaptive Immune Response Glycogen Metabolic Process Positive Regulation Of Cell Proliferation Regulation Of Notch Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Cardiac Muscle Hypertrophy Viral Process Cytokine-mediated Signaling Pathway Response To Cytokine Interleukin-11-mediated Signaling Pathway Oncostatin-M-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Apoptotic Process Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Astrocyte Differentiation Leukemia Inhibitory Factor Signaling Pathway Interleukin-6-mediated Signaling Pathway Interleukin-27-mediated Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway Interleukin-35-mediated Signaling Pathway	Neutrophil Apoptotic Process Hepatic Immune Response Neutrophil Mediated Immunity Monocyte Chemotaxis Positive Regulation Of Acute Inflammatory Response Positive Regulation Of Leukocyte Chemotaxis Acute-phase Response Inflammatory Response Humoral Immune Response Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Lipid Storage Cytokine-mediated Signaling Pathway Platelet Activation Endocrine Pancreas Development Neuron Projection Development Response To Peptidoglycan Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Negative Regulation Of Collagen Biosynthetic Process Positive Regulation Of Peptidyl-serine Phosphorylation Maintenance Of Permeability Of Blood-brain Barrier Positive Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Post-translational Protein Modification Cellular Protein Metabolic Process Negative Regulation Of Chemokine Biosynthetic Process Positive Regulation Of Interleukin-17 Biosynthetic Process Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Translation Regulation Of Angiogenesis Negative Regulation Of Bone Resorption Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JAK-STAT Cascade Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Neurogenesis Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Regulation Of B Cell Activation Positive Regulation Of Immunoglobulin Secretion Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Glucocorticoid Defense Response To Virus Positive Regulation Of Glial Cell Proliferation Regulation Of Astrocyte Activation Neuron Cellular Homeostasis Glucagon Secretion Interleukin-6-mediated Signaling Pathway Cellular Response To Hydrogen Peroxide Cellular Response To Lipopolysaccharide T-helper 17 Cell Lineage Commitment Positive Regulation Of Extracellular Matrix Disassembly Regulation Of Neuroinflammatory Response Positive Regulation Of Neuroinflammatory Response Positive Regulation Of Apoptotic DNA Fragmentation Regulation Of Microglial Cell Activation Positive Regulation Of T-helper 2 Cell Cytokine Production Negative Regulation Of Interleukin-1-mediated Signaling Pathway Positive Regulation Of Type B Pancreatic Cell Apoptotic Process
Pathways		Interleukin-6 signaling Interleukin-6 signaling IL-6-type cytokine receptor ligand interactions Interleukin-35 Signalling Interleukin-27 signaling Interleukin-27 signaling	Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation Senescence-Associated Secretory Phenotype (SASP) Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Transcriptional Regulation by VENTX Post-translational protein phosphorylation ADORA2B mediated anti-inflammatory cytokines production CD163 mediating an anti-inflammatory response
Drugs			Ginseng YSIL6 VX-702 CRx-139 Andrographolide Tapinarof Siltuximab Binimetinib Dilmapimod
Diseases			Graft-versus-host disease
GWAS		Blood protein levels ( 30072576 29875488 28240269) Crohn's disease ( 23128233) IgG glycosylation ( 23382691) Rheumatoid arthritis ( 20453842)	Asthma ( 30929738 31619474) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Birth weight ( 31043758) Blond vs. brown/black hair color ( 30531825) C-reactive protein ( 21196492) C-reactive protein levels ( 30388399) Cerebrospinal fluid clusterin levels in APOEe4- carriers ( 26545630) Dialysis-related mortality ( 21546767) Fibrinogen ( 23969696) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Longevity ( 26912274) Longevity (age >90th survival percentile) ( 31413261) Longevity (age >99th survival percentile) ( 31413261) Multiple sclerosis ( 31604244) Offspring birth weight ( 31043758) Peripheral artery disease ( 31285632) Pulse pressure ( 30224653 30578418) Takayasu arteritis ( 25604533)
Interacting Genes		31 interacting genes: AR CDK9 CNTF CNTFR CTF1 ERBB2 ERBB3 HCK IL31RA IL6 IL6R JAK1 KCNIP3 LIF LIFR MAGEA11 OSM OSMR PIK3CG PLAUR PRKCD PTPN11 PTPN6 SGTB SHC1 SOCS3 STAT3 TLE1 TYK2 UBQLN1 VAV1	5 interacting genes: IL6R IL6ST PTHLH SH3GL2 ZBTB16
Entrez ID		3572	3569
HPRD ID		02824	00970
Ensembl ID		ENSG00000134352	ENSG00000136244
Uniprot IDs		A0A0A0N0L2 P40189 Q17RA0	B4DNQ5 B4DVM1 B5MC21 P05231 Q75MH2
PDB IDs		1BJ8 1BQU 1I1R 1N2Q 1P9M 1PVH 3L5H 3L5I 3L5J	1ALU 1IL6 1N2Q 1P9M 2IL6 4CNI 4J4L 4NI7 4NI9 4O9H 4ZS7 5FUC
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?