IL6 and IL6R

Number of citations of the paper that reports this interaction (PubMedID 12829785)
159

Data Source:
HPRD (in vivo, in vitro)

		IL6	IL6R
Description		interleukin 6	interleukin 6 receptor
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Endoplasmic Reticulum Lumen Interleukin-6 Receptor Complex	Extracellular Region Plasma Membrane Interleukin-6 Receptor Complex External Side Of Plasma Membrane Basolateral Plasma Membrane Apical Plasma Membrane Receptor Complex Ciliary Neurotrophic Factor Receptor Complex
	Molecular Function	Cytokine Activity Interleukin-6 Receptor Binding Protein Binding Growth Factor Activity	Cytokine Receptor Activity Ciliary Neurotrophic Factor Receptor Activity Interleukin-6 Receptor Activity Interleukin-6 Receptor Binding Protein Binding Enzyme Binding Cytokine Binding Interleukin-6 Binding Protein Homodimerization Activity Ciliary Neurotrophic Factor Binding
	Biological Process	Neutrophil Apoptotic Process Hepatic Immune Response Neutrophil Mediated Immunity Monocyte Chemotaxis Positive Regulation Of Acute Inflammatory Response Positive Regulation Of Leukocyte Chemotaxis Acute-phase Response Inflammatory Response Humoral Immune Response Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Lipid Storage Cytokine-mediated Signaling Pathway Platelet Activation Endocrine Pancreas Development Neuron Projection Development Response To Peptidoglycan Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Negative Regulation Of Collagen Biosynthetic Process Positive Regulation Of Peptidyl-serine Phosphorylation Maintenance Of Permeability Of Blood-brain Barrier Positive Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Post-translational Protein Modification Cellular Protein Metabolic Process Negative Regulation Of Chemokine Biosynthetic Process Positive Regulation Of Interleukin-17 Biosynthetic Process Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Translation Regulation Of Angiogenesis Negative Regulation Of Bone Resorption Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JAK-STAT Cascade Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Neurogenesis Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Regulation Of B Cell Activation Positive Regulation Of Immunoglobulin Secretion Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Glucocorticoid Defense Response To Virus Positive Regulation Of Glial Cell Proliferation Regulation Of Astrocyte Activation Neuron Cellular Homeostasis Glucagon Secretion Interleukin-6-mediated Signaling Pathway Cellular Response To Hydrogen Peroxide Cellular Response To Lipopolysaccharide T-helper 17 Cell Lineage Commitment Positive Regulation Of Extracellular Matrix Disassembly Regulation Of Neuroinflammatory Response Positive Regulation Of Neuroinflammatory Response Positive Regulation Of Apoptotic DNA Fragmentation Regulation Of Microglial Cell Activation Positive Regulation Of T-helper 2 Cell Cytokine Production Negative Regulation Of Interleukin-1-mediated Signaling Pathway Positive Regulation Of Type B Pancreatic Cell Apoptotic Process	Hepatic Immune Response Monocyte Chemotaxis Positive Regulation Of Leukocyte Chemotaxis Acute-phase Response Positive Regulation Of Cell Proliferation Positive Regulation Of Activation Of Janus Kinase Activity Cytokine-mediated Signaling Pathway Endocrine Pancreas Development Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Response To Cytokine Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Gram-negative Bacterium Interleukin-6-mediated Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway Positive Regulation Of Glomerular Mesangial Cell Proliferation Extrinsic Apoptotic Signaling Pathway
Pathways		Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation Senescence-Associated Secretory Phenotype (SASP) Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Transcriptional Regulation by VENTX Post-translational protein phosphorylation ADORA2B mediated anti-inflammatory cytokines production CD163 mediating an anti-inflammatory response	Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation Interleukin-4 and Interleukin-13 signaling Transcriptional regulation of granulopoiesis
Drugs		Ginseng YSIL6 VX-702 CRx-139 Andrographolide Tapinarof Siltuximab Binimetinib Dilmapimod	Tocilizumab Sarilumab
Diseases		Graft-versus-host disease
GWAS		Asthma ( 30929738 31619474) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Birth weight ( 31043758) Blond vs. brown/black hair color ( 30531825) C-reactive protein ( 21196492) C-reactive protein levels ( 30388399) Cerebrospinal fluid clusterin levels in APOEe4- carriers ( 26545630) Dialysis-related mortality ( 21546767) Fibrinogen ( 23969696) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Longevity ( 26912274) Longevity (age >90th survival percentile) ( 31413261) Longevity (age >99th survival percentile) ( 31413261) Multiple sclerosis ( 31604244) Offspring birth weight ( 31043758) Peripheral artery disease ( 31285632) Pulse pressure ( 30224653 30578418) Takayasu arteritis ( 25604533)	Abdominal aortic aneurysm ( 27899403) Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever or eczema) ( 29083406) Ankylosing spondylitis ( 23749187) Asthma ( 21907864) Atopic dermatitis ( 26482879) Atrial fibrillation ( 29892015) Blood protein levels ( 30072576 29875488 28240269 23696881) Blood protein levels in cardiovascular risk ( 28369058) C-reactive protein ( 19567438 18439548) C-reactive protein levels ( 29403010 30388399 21300955) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Coronary artery disease ( 29212778 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Fibrinogen ( 20031577 23969696) Fibrinogen levels ( 28107422 26561523) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Monocyte percentage of white cells ( 27863252) Mosquito bite size ( 28199695) Myocardial infarction ( 26343387) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Protein quantitative trait loci ( 18464913) Pulmonary function ( 17903307) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy) ( 24554482) Rheumatoid arthritis ( 30423114 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Systemic lupus erythematosus ( 28714469)
Interacting Genes		5 interacting genes: IL6R IL6ST PTHLH SH3GL2 ZBTB16	10 interacting genes: ADRB2 CNTF ERAP1 IL6 IL6ST MAGI1 SRC STAT3 WWP1 WWP2
Entrez ID		3569	3570
HPRD ID		00970	01000
Ensembl ID		ENSG00000136244	ENSG00000160712
Uniprot IDs		B4DNQ5 B4DVM1 B5MC21 P05231 Q75MH2	A0A087WTB5 A0N0L5 P08887
PDB IDs		1ALU 1IL6 1N2Q 1P9M 2IL6 4CNI 4J4L 4NI7 4NI9 4O9H 4ZS7 5FUC	1N26 1N2Q 1P9M 2ARW 5FUC
Enriched GO Terms of Interacting Partners?
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