IL6 and SH3GL2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		IL6	SH3GL2
Description		interleukin 6	SH3 domain containing GRB2 like 2, endophilin A1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Endoplasmic Reticulum Lumen Interleukin-6 Receptor Complex	Golgi Membrane Early Endosome Cytosol Plasma Membrane Cell Junction Clathrin-coated Endocytic Vesicle Membrane Synaptic Vesicle Membrane Neuronal Cell Body Perinuclear Region Of Cytoplasm Basal Dendrite Photoreceptor Ribbon Synapse Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse Presynaptic Cytosol
	Molecular Function	Cytokine Activity Interleukin-6 Receptor Binding Protein Binding Growth Factor Activity	Protein Binding Protein C-terminus Binding Lipid Binding Protein Kinase Binding Identical Protein Binding
	Biological Process	Neutrophil Apoptotic Process Hepatic Immune Response Neutrophil Mediated Immunity Monocyte Chemotaxis Positive Regulation Of Acute Inflammatory Response Positive Regulation Of Leukocyte Chemotaxis Acute-phase Response Inflammatory Response Humoral Immune Response Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Lipid Storage Cytokine-mediated Signaling Pathway Platelet Activation Endocrine Pancreas Development Neuron Projection Development Response To Peptidoglycan Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Negative Regulation Of Collagen Biosynthetic Process Positive Regulation Of Peptidyl-serine Phosphorylation Maintenance Of Permeability Of Blood-brain Barrier Positive Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Post-translational Protein Modification Cellular Protein Metabolic Process Negative Regulation Of Chemokine Biosynthetic Process Positive Regulation Of Interleukin-17 Biosynthetic Process Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Translation Regulation Of Angiogenesis Negative Regulation Of Bone Resorption Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JAK-STAT Cascade Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Neurogenesis Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Regulation Of B Cell Activation Positive Regulation Of Immunoglobulin Secretion Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Glucocorticoid Defense Response To Virus Positive Regulation Of Glial Cell Proliferation Regulation Of Astrocyte Activation Neuron Cellular Homeostasis Glucagon Secretion Interleukin-6-mediated Signaling Pathway Cellular Response To Hydrogen Peroxide Cellular Response To Lipopolysaccharide T-helper 17 Cell Lineage Commitment Positive Regulation Of Extracellular Matrix Disassembly Regulation Of Neuroinflammatory Response Positive Regulation Of Neuroinflammatory Response Positive Regulation Of Apoptotic DNA Fragmentation Regulation Of Microglial Cell Activation Positive Regulation Of T-helper 2 Cell Cytokine Production Negative Regulation Of Interleukin-1-mediated Signaling Pathway Positive Regulation Of Type B Pancreatic Cell Apoptotic Process	Negative Regulation Of Protein Phosphorylation Regulation Of Receptor Internalization Signal Transduction Central Nervous System Development Negative Regulation Of Gene Expression Synaptic Vesicle Uncoating Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Neuron Projection Development Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Lipid Tube Assembly Membrane Organization Dendrite Extension Membrane Tubulation Membrane Bending Vesicle Scission Positive Regulation Of Membrane Tubulation Negative Regulation Of Maintenance Of Permeability Of Blood-brain Barrier Cellular Response To Brain-derived Neurotrophic Factor Stimulus Regulation Of Clathrin-dependent Endocytosis
Pathways		Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation Senescence-Associated Secretory Phenotype (SASP) Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Transcriptional Regulation by VENTX Post-translational protein phosphorylation ADORA2B mediated anti-inflammatory cytokines production CD163 mediating an anti-inflammatory response	Retrograde neurotrophin signalling Retrograde neurotrophin signalling EGFR downregulation MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Recycling pathway of L1 Recycling pathway of L1 Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell
Drugs		Ginseng YSIL6 VX-702 CRx-139 Andrographolide Tapinarof Siltuximab Binimetinib Dilmapimod
Diseases		Graft-versus-host disease
GWAS		Asthma ( 30929738 31619474) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Birth weight ( 31043758) Blond vs. brown/black hair color ( 30531825) C-reactive protein ( 21196492) C-reactive protein levels ( 30388399) Cerebrospinal fluid clusterin levels in APOEe4- carriers ( 26545630) Dialysis-related mortality ( 21546767) Fibrinogen ( 23969696) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Longevity ( 26912274) Longevity (age >90th survival percentile) ( 31413261) Longevity (age >99th survival percentile) ( 31413261) Multiple sclerosis ( 31604244) Offspring birth weight ( 31043758) Peripheral artery disease ( 31285632) Pulse pressure ( 30224653 30578418) Takayasu arteritis ( 25604533)	Cerebral cortical growth ( 29682794) Cognitive performance ( 19734545) FEV1 ( 30804560) Heart failure ( 20445134) Lung function (FVC) ( 30804560) Midgestational circulating levels of PBDEs ( 28235828) Multiple sclerosis ( 19010793) Myopia ( 27182965) Obesity-related traits ( 23251661) Parkinson's disease ( 22451204 27182965 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Pursuit maintenance gain ( 29064472) Small cell lung carcinoma ( 28604730) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		5 interacting genes: IL6R IL6ST PTHLH SH3GL2 ZBTB16	51 interacting genes: ACTG1 ADAM15 ADAM19 ADRB1 AMPH APP ARNT2 ATXN2 BIN1 CD2AP CLEC3B DACT1 DLGAP4 DNM1 DNM2 DPPA4 DPYSL4 EGFL6 EMD ERH F13A1 FBXO32 GCH1 GSTM3 HLA-DQA1 IGHM IL6 ITCH ITSN1 LCP2 LRRK2 MAP4K3 MAST2 PAK2 PAXIP1 PDCD6IP PPP1R21 PPP6R1 PRR14 SH3GL3 SH3KBP1 SLC17A7 SYNJ1 TCEA2 TERF1 TIAM2 TMEM108 TYMS ZNF219 ZNF580 ZXDC
Entrez ID		3569	6456
HPRD ID		00970	05125
Ensembl ID		ENSG00000136244	ENSG00000107295
Uniprot IDs		B4DNQ5 B4DVM1 B5MC21 P05231 Q75MH2	Q7Z376 Q99962
PDB IDs		1ALU 1IL6 1N2Q 1P9M 2IL6 4CNI 4J4L 4NI7 4NI9 4O9H 4ZS7 5FUC	1X03 1X04 2D4C 2DBM
Enriched GO Terms of Interacting Partners?
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