KLK3 and PZP

Number of citations of the paper that reports this interaction (PubMedID 1702714)
67

Data Source:
HPRD (in vitro)

		KLK3	PZP
Description		kallikrein related peptidase 3	PZP alpha-2-macroglobulin like
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Secretory Granule Protein-containing Complex Extracellular Exosome	Extracellular Region Extracellular Space Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle
	Molecular Function	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Serine-type Peptidase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity
	Biological Process	Antibacterial Peptide Production Regulation Of Systemic Arterial Blood Pressure Proteolysis Negative Regulation Of Angiogenesis Zymogen Activation Cellular Protein Metabolic Process	Female Pregnancy Negative Regulation Of Endopeptidase Activity
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Drugs		Mifepristone Cyproterone acetate
Diseases
GWAS		Celiac disease ( 23936387) Elevated serum prostate-specific antigen levels in healthy men ( 28471803) PCA3 expression level ( 23555189) Prostate cancer ( 18264097 31562322 26034056 24753544) Prostate cancer (early onset) ( 24740154) Prostate cancer aggressiveness ( 25939597) Prostate-specific antigen levels ( 25434496 23269536 28139693 24919509) Prostate-specific antigen levels (conditioned on lead SNPs) ( 28139693) Serum prostate-specific antigen levels ( 21160077)	Blood protein levels ( 30072576 29875488) Depression in smokers ( 30219690) Myopia ( 27182965) Non-alcoholic fatty liver disease histology (AST) ( 20708005) Obesity-related traits ( 23251661) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		14 interacting genes: A2M ALB EPOR FN1 IGFBP3 PLG PTHLH PZP SEMG1 SEMG2 SERPINA1 SERPINA3 SERPINA5 SLPI	6 interacting genes: CPB2 KLK3 MMP2 MMP9 TGFB1 TGFB2
Entrez ID		354	5858
HPRD ID		01461	07178
Ensembl ID		ENSG00000142515	ENSG00000126838
Uniprot IDs		P07288 Q546G3
PDB IDs		1PFA 2PSA 2ZCH 2ZCK 2ZCL 3QUM
Enriched GO Terms of Interacting Partners?
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