KLK3 and SEMG1

Number of citations of the paper that reports this interaction (PubMedID 11027412)
36

Data Source:
HPRD (in vitro)

		KLK3	SEMG1
Description		kallikrein related peptidase 3	semenogelin 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Secretory Granule Protein-containing Complex Extracellular Exosome	Extracellular Region Extracellular Space Nucleus Protein-containing Complex Extracellular Exosome
	Molecular Function	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Serine-type Peptidase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides	Protein Binding Zinc Ion Binding
	Biological Process	Antibacterial Peptide Production Regulation Of Systemic Arterial Blood Pressure Proteolysis Negative Regulation Of Angiogenesis Zymogen Activation Cellular Protein Metabolic Process	Insemination Antimicrobial Humoral Response Antibacterial Humoral Response Killing Of Cells Of Other Organism Cellular Protein Metabolic Process Sperm Capacitation Coagulation Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Negative Regulation Of Calcium Ion Import Positive Regulation Of Serine-type Endopeptidase Activity Negative Regulation Of Flagellated Sperm Motility
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	Antimicrobial peptides Amyloid fiber formation
Drugs		Mifepristone Cyproterone acetate	Zinc
Diseases
GWAS		Celiac disease ( 23936387) Elevated serum prostate-specific antigen levels in healthy men ( 28471803) PCA3 expression level ( 23555189) Prostate cancer ( 18264097 31562322 26034056 24753544) Prostate cancer (early onset) ( 24740154) Prostate cancer aggressiveness ( 25939597) Prostate-specific antigen levels ( 25434496 23269536 28139693 24919509) Prostate-specific antigen levels (conditioned on lead SNPs) ( 28139693) Serum prostate-specific antigen levels ( 21160077)	Bipolar disorder ( 31043756) Blood protein levels ( 28240269)
Interacting Genes		14 interacting genes: A2M ALB EPOR FN1 IGFBP3 PLG PTHLH PZP SEMG1 SEMG2 SERPINA1 SERPINA3 SERPINA5 SLPI	7 interacting genes: KLK2 KLK3 PRKCA PTPRF SEMG2 TGM1 UBQLN4
Entrez ID		354	6406
HPRD ID		01461	01641
Ensembl ID		ENSG00000142515	ENSG00000124233
Uniprot IDs		P07288 Q546G3	P04279
PDB IDs		1PFA 2PSA 2ZCH 2ZCK 2ZCL 3QUM
Enriched GO Terms of Interacting Partners?
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