HTR1B and HTR1A

Number of citations of the paper that reports this interaction (PubMedID 11854302)
15

Data Source:
HPRD (in vivo, in vitro)

		HTR1B	HTR1A
Description		5-hydroxytryptamine receptor 1B	5-hydroxytryptamine receptor 1A
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Dendrite Calyx Of Held Integral Component Of Presynaptic Membrane Serotonergic Synapse	Plasma Membrane Integral Component Of Plasma Membrane Dendrite Synapse
	Molecular Function	G Protein-coupled Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Drug Binding Neurotransmitter Receptor Activity Serotonin Binding Voltage-gated Calcium Channel Activity Involved In Regulation Of Presynaptic Cytosolic Calcium Levels	G Protein-coupled Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity Serotonin Binding Receptor-receptor Interaction
	Biological Process	G Protein-coupled Receptor Internalization G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Chemical Synaptic Transmission Negative Regulation Of Gamma-aminobutyric Acid Secretion Regulation Of Dopamine Secretion Negative Regulation Of Serotonin Secretion Negative Regulation Of Synaptic Transmission, GABAergic Cellular Response To Drug Response To Cocaine Vasoconstriction Drinking Behavior Response To Ethanol Bone Remodeling Regulation Of Behavior Response To Mineralocorticoid Negative Regulation Of Synaptic Transmission, Glutamatergic Cellular Response To Alkaloid Cellular Response To Temperature Stimulus Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Positive Regulation Of Vascular Smooth Muscle Cell Proliferation Regulation Of Synaptic Vesicle Exocytosis	Behavioral Fear Response G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Cell Proliferation Positive Regulation Of Cell Proliferation Regulation Of Serotonin Secretion Exploration Behavior Regulation Of Dopamine Metabolic Process Vasoconstriction Serotonin Metabolic Process Regulation Of Hormone Secretion Regulation Of Behavior
Pathways		Serotonin receptors G alpha (i) signalling events	Serotonin receptors G alpha (i) signalling events
Drugs		Eletriptan Ziprasidone Methysergide Cabergoline Ropinirole Zolmitriptan Dihydroergotamine Amitriptyline Olanzapine Clozapine Loxapine Pramipexole Amoxapine Propranolol Lisuride Sumatriptan Ergotamine Apomorphine Ondansetron Almotriptan Naratriptan Rizatriptan Pindolol Frovatriptan Ergoloid mesylate Pergolide Bromocriptine Ketamine Quetiapine Aripiprazole Penbutolol Yohimbine Dapoxetine NXN-188 Asenapine Bopindolol Vortioxetine Setiptiline Tiapride	Eletriptan Ziprasidone Methysergide Cabergoline Ropinirole Zolmitriptan Amitriptyline Olanzapine Clozapine Loxapine Pramipexole Imipramine Chlorpromazine Buspirone Nortriptyline Amoxapine Propranolol Lisuride Trazodone Sumatriptan Ergotamine Apomorphine Trimipramine Risperidone Alprenolol Ondansetron Naratriptan Pindolol Dopamine Ergoloid mesylate Doxepin Nefazodone Desipramine Pergolide Bromocriptine Ketamine Quetiapine Aripiprazole Paliperidone Penbutolol Yohimbine Acepromazine Alverine Molindone Pipotiazine Thioproperazine Lysergic Acid Diethylamide Dapoxetine Bifeprunox Flibanserin Iloperidone Lesopitron Rotigotine MN-305 LI-301 Cariprazine Mianserin Asenapine Vilazodone Bopindolol Cinitapride Lurasidone Perospirone Vortioxetine Brexpiprazole Dosulepin Setiptiline Pardoprunox Tiapride
Diseases
GWAS		Brain volume in infants (white matter) ( 28763065) Psychological distress ( 30705256) Response to fenofibrate (total cholesterol levels) ( 27002377)	Alcohol and nicotine co-dependence ( 23216389) Body mass index ( 20935630) Bronchopulmonary dysplasia ( 23897914) Fasting insulin (dietary factor interaction) ( 24204828) Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828) White matter lesion progression ( 26451028) White matter lesion progression (adjusted for white matter lesion burden at baseline) ( 26451028)
Interacting Genes		3 interacting genes: HTR1A HTR1D MDFI	8 interacting genes: FGFR1 GABBR2 GNAI3 GPR26 HTR1B HTR1D S1PR1 S1PR3
Entrez ID		3351	3350
HPRD ID		01634	00190
Ensembl ID		ENSG00000135312	ENSG00000178394
Uniprot IDs		A8K215 P28222 X5D7I5	A8K5W4 P08908 Q5ZGX3
PDB IDs		2G1X 4IAQ 4IAR 5V54 6G79
Enriched GO Terms of Interacting Partners?
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