HTR1A and GABBR2

Number of citations of the paper that reports this interaction (PubMedID 11854302)
15

Data Source:
HPRD (in vivo)

		HTR1A	GABBR2
Description		5-hydroxytryptamine receptor 1A	gamma-aminobutyric acid type B receptor subunit 2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Dendrite Synapse	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Junction G Protein-coupled Receptor Heterodimeric Complex Neuron Projection Postsynaptic Membrane GABA Receptor Complex
	Molecular Function	G Protein-coupled Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity Serotonin Binding Receptor-receptor Interaction	Transmembrane Signaling Receptor Activity G Protein-coupled GABA Receptor Activity Protein Binding Protein Heterodimerization Activity
	Biological Process	Behavioral Fear Response G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Cell Proliferation Positive Regulation Of Cell Proliferation Regulation Of Serotonin Secretion Exploration Behavior Regulation Of Dopamine Metabolic Process Vasoconstriction Serotonin Metabolic Process Regulation Of Hormone Secretion Regulation Of Behavior	G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Gamma-aminobutyric Acid Signaling Pathway Chemical Synaptic Transmission
Pathways		Serotonin receptors G alpha (i) signalling events	Activation of G protein gated Potassium channels G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) GABA B receptor activation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs		Eletriptan Ziprasidone Methysergide Cabergoline Ropinirole Zolmitriptan Amitriptyline Olanzapine Clozapine Loxapine Pramipexole Imipramine Chlorpromazine Buspirone Nortriptyline Amoxapine Propranolol Lisuride Trazodone Sumatriptan Ergotamine Apomorphine Trimipramine Risperidone Alprenolol Ondansetron Naratriptan Pindolol Dopamine Ergoloid mesylate Doxepin Nefazodone Desipramine Pergolide Bromocriptine Ketamine Quetiapine Aripiprazole Paliperidone Penbutolol Yohimbine Acepromazine Alverine Molindone Pipotiazine Thioproperazine Lysergic Acid Diethylamide Dapoxetine Bifeprunox Flibanserin Iloperidone Lesopitron Rotigotine MN-305 LI-301 Cariprazine Mianserin Asenapine Vilazodone Bopindolol Cinitapride Lurasidone Perospirone Vortioxetine Brexpiprazole Dosulepin Setiptiline Pardoprunox Tiapride	Baclofen Gabapentin gamma-Aminobutyric acid SGS-742 Arbaclofen Arbaclofen Placarbil
Diseases
GWAS		Alcohol and nicotine co-dependence ( 23216389) Body mass index ( 20935630) Bronchopulmonary dysplasia ( 23897914) Fasting insulin (dietary factor interaction) ( 24204828) Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828) White matter lesion progression ( 26451028) White matter lesion progression (adjusted for white matter lesion burden at baseline) ( 26451028)	High chromosomal aberration frequency (chromatid type) ( 31586183) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Response to simvastatin treatment (PCSK9 protein level change) ( 25089948) Response to TNF inhibitor in rheumatoid arthritis (change in tender 28-joint count) ( 30166627) Schizophrenia ( 30285260) Systolic blood pressure change trajectories ( 27980656)
Interacting Genes		8 interacting genes: FGFR1 GABBR2 GNAI3 GPR26 HTR1B HTR1D S1PR1 S1PR3	9 interacting genes: ATF4 ATF5 GABBR1 GLP1R HTR1A KCTD12 NSF SH3GL3 TAMALIN
Entrez ID		3350	9568
HPRD ID		00190	09552
Ensembl ID		ENSG00000178394	ENSG00000136928
Uniprot IDs		A8K5W4 P08908 Q5ZGX3	H9NIL8 O75899
PDB IDs			4F11 4F12 4MQE 4MQF 4MR7 4MR8 4MR9 4MRM 4MS1 4MS3 4MS4 4PAS 6M8R 6OCP
Enriched GO Terms of Interacting Partners?
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