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HES1 and NR4A1
Number of citations of the paper that reports this interaction (PubMedID
21900206
)
114
Data Source:
BioGRID
(two hybrid)
HES1
NR4A1
Description
hes family bHLH transcription factor 1
nuclear receptor subfamily 4 group A member 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Protein-containing Complex
Nuclear Chromatin
Nucleus
Nucleoplasm
Transcription Factor Complex
Mitochondrion
Cytosol
Nuclear Membrane
Molecular Function
RNA Polymerase II Regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA Binding
Protein Binding
Transcription Factor Binding
Protein Homodimerization Activity
Histone Deacetylase Binding
HLH Domain Binding
Sequence-specific DNA Binding
Chaperone Binding
E-box Binding
N-box Binding
RNA Polymerase II Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Steroid Hormone Receptor Activity
Nuclear Receptor Activity
Protein Binding
Zinc Ion Binding
Glucocorticoid Receptor Binding
Sequence-specific DNA Binding
Protein Heterodimerization Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Liver Development
Embryonic Heart Tube Morphogenesis
Outflow Tract Morphogenesis
Regulation Of Secondary Heart Field Cardioblast Proliferation
Ventricular Septum Development
Cell Adhesion
Notch Signaling Pathway
Smoothened Signaling Pathway
Nervous System Development
Positive Regulation Of Cell Proliferation
Anterior/posterior Pattern Specification
Cell Migration
Telencephalon Development
Midbrain-hindbrain Boundary Morphogenesis
Oculomotor Nerve Development
Trochlear Nerve Development
Hindbrain Morphogenesis
Forebrain Radial Glial Cell Differentiation
Adenohypophysis Development
Cell Differentiation
Lung Development
Positive Regulation Of BMP Signaling Pathway
Midbrain Development
Pancreas Development
Somatic Stem Cell Population Maintenance
Ascending Aorta Morphogenesis
Positive Regulation Of T Cell Proliferation
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Positive Regulation Of DNA Binding
Regulation Of Fat Cell Differentiation
Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation
Negative Regulation Of Neuron Differentiation
Positive Regulation Of Notch Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Mitotic Cell Cycle, Embryonic
Lateral Inhibition
Regulation Of JAK-STAT Cascade
Positive Regulation Of JAK-STAT Cascade
Cell Maturation
Thymus Development
Cell Morphogenesis Involved In Neuron Differentiation
Positive Regulation Of Astrocyte Differentiation
Negative Regulation Of Oligodendrocyte Differentiation
Artery Morphogenesis
Regulation Of Epithelial Cell Proliferation
Regulation Of Neurogenesis
Inner Ear Receptor Cell Stereocilium Organization
Regulation Of Timing Of Neuron Differentiation
Negative Regulation Of Glial Cell Proliferation
Ventricular Septum Morphogenesis
Ureteric Bud Morphogenesis
Labyrinthine Layer Blood Vessel Development
Common Bile Duct Development
Negative Regulation Of Stomach Neuroendocrine Cell Differentiation
Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis
Pharyngeal Arch Artery Morphogenesis
Protein-containing Complex Assembly
Glomerulus Vasculature Development
Comma-shaped Body Morphogenesis
S-shaped Body Morphogenesis
Renal Interstitial Fibroblast Development
Metanephric Nephron Tubule Morphogenesis
Cochlea Development
Establishment Of Epithelial Cell Polarity
Vascular Smooth Muscle Cell Development
Neuronal Stem Cell Population Maintenance
Negative Regulation Of Cell Fate Determination
Negative Regulation Of Pancreatic A Cell Differentiation
Negative Regulation Of Stem Cell Differentiation
Negative Regulation Of Pro-B Cell Differentiation
Negative Regulation Of Forebrain Neuron Differentiation
Positive Regulation Of Endothelial Cell Proliferation
Cell Migration Involved In Sprouting Angiogenesis
Transcription Initiation From RNA Polymerase II Promoter
Signal Transduction
Intracellular Receptor Signaling Pathway
Endothelial Cell Chemotaxis
Cellular Response To Vascular Endothelial Growth Factor Stimulus
Steroid Hormone Mediated Signaling Pathway
Cellular Response To Fibroblast Growth Factor Stimulus
Fat Cell Differentiation
Negative Regulation Of Cell Cycle
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Type B Pancreatic Cell Proliferation
Cellular Response To Corticotropin-releasing Hormone Stimulus
Pathways
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
NOTCH1 Intracellular Domain Regulates Transcription
NOTCH2 intracellular domain regulates transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
RUNX2 regulates osteoblast differentiation
RUNX3 regulates NOTCH signaling
RUNX3 regulates NOTCH signaling
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH4 Intracellular Domain Regulates Transcription
AKT phosphorylates targets in the nucleus
Nuclear Receptor transcription pathway
Constitutive Signaling by AKT1 E17K in Cancer
Drugs
Diseases
GWAS
Alcoholic chronic pancreatitis (
28754779
)
Dental caries (decayed, missing and filled teeth) (
31533690
)
Dental caries (decayed, missing and filled tooth surfaces) (
31533690
)
Thyroid stimulating hormone levels (
30367059
)
Interacting Genes
35 interacting genes:
APCS
APH1A
ASGR2
CSNK1E
FANCA
FANCE
FANCF
FANCG
FANCL
FHL1
FOXG1
GAPDH
HDAC6
HES6
HEY1
HEY2
HMGB1
HMGCL
ID1
ID2
ID3
ID4
JAK2
LTBR
NHLH2
NR4A1
NUDT3
PRKCA
PTK2
SIRT1
STAT3
TLE1
TLE2
UBQLN1
YWHAB
87 interacting genes:
ABCA5
ABCB11
ABCC13
ABCC6
ABCG8
AKT1
ANKIB1
ARHGEF10L
ARHGEF5
ATM
ATXN1
BBS10
BCL2
BCL2A1
BCL2L10
CD2AP
CDKN2D
CHD1L
CHD3
CHEK2
CPT1A
CUTA
DIABLO
EP300
FAF1
FXYD3
GADD45GIP1
GK
GLOD4
GLUD1
HADHA
HES1
HIF1A
HNRNPA2B1
HSP90AB1
KAT2B
KRTAP10-1
KRTAP10-5
LONRF1
LSS
MAP3K1
MAPK1
MAPK8
MED1
MED31
NACAD
NCOA1
NCOA2
NCOA3
NCOR2
NDRG1
NFKB1
NR3C1
PGBD1
PML
POLA2
PPARG
PPBP
PPM1A
PRDX4
PRDX6
RBL1
ROBO2
RPL7
RPS6KA1
RPS6KA3
RPS6KA5
RPS6KA6
RTN4
RXRA
RXRG
SERPINA4
SERPING1
SMAD3
SOCS4
STAT3
SUGT1
TCF4
TP53
TRAF2
TRIM28
TUBB4A
VASP
VHL
YWHAZ
ZNF331
ZNF579
Entrez ID
3280
3164
HPRD ID
00770
00744
Ensembl ID
ENSG00000114315
ENSG00000123358
Uniprot IDs
Q14469
A0A024R126
F5GXF0
P22736
Q6ZMM6
PDB IDs
2MH3
2QW4
3V3E
3V3Q
4JGV
4KZI
4KZJ
4KZM
4RE8
4REE
4REF
4RZE
4RZF
4RZG
4WHF
4WHG
Enriched GO Terms of Interacting Partners
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