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HES1 and UBQLN1
Number of citations of the paper that reports this interaction (PubMedID
15492808
)
3
Data Source:
HPRD
(two hybrid)
HES1
UBQLN1
Description
hes family bHLH transcription factor 1
ubiquilin 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Protein-containing Complex
Proteasome Complex
Nucleoplasm
Cytoplasm
Autophagosome
Endoplasmic Reticulum
Cytosol
Plasma Membrane
Aggresome
Cytoplasmic Vesicle
Protein-containing Complex
Perinuclear Region Of Cytoplasm
Molecular Function
RNA Polymerase II Regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA Binding
Protein Binding
Transcription Factor Binding
Protein Homodimerization Activity
Histone Deacetylase Binding
HLH Domain Binding
Sequence-specific DNA Binding
Chaperone Binding
E-box Binding
N-box Binding
Protein Binding
Kinase Binding
Polyubiquitin Modification-dependent Protein Binding
Identical Protein Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Liver Development
Embryonic Heart Tube Morphogenesis
Outflow Tract Morphogenesis
Regulation Of Secondary Heart Field Cardioblast Proliferation
Ventricular Septum Development
Cell Adhesion
Notch Signaling Pathway
Smoothened Signaling Pathway
Nervous System Development
Positive Regulation Of Cell Proliferation
Anterior/posterior Pattern Specification
Cell Migration
Telencephalon Development
Midbrain-hindbrain Boundary Morphogenesis
Oculomotor Nerve Development
Trochlear Nerve Development
Hindbrain Morphogenesis
Forebrain Radial Glial Cell Differentiation
Adenohypophysis Development
Cell Differentiation
Lung Development
Positive Regulation Of BMP Signaling Pathway
Midbrain Development
Pancreas Development
Somatic Stem Cell Population Maintenance
Ascending Aorta Morphogenesis
Positive Regulation Of T Cell Proliferation
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Positive Regulation Of DNA Binding
Regulation Of Fat Cell Differentiation
Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation
Negative Regulation Of Neuron Differentiation
Positive Regulation Of Notch Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Mitotic Cell Cycle, Embryonic
Lateral Inhibition
Regulation Of JAK-STAT Cascade
Positive Regulation Of JAK-STAT Cascade
Cell Maturation
Thymus Development
Cell Morphogenesis Involved In Neuron Differentiation
Positive Regulation Of Astrocyte Differentiation
Negative Regulation Of Oligodendrocyte Differentiation
Artery Morphogenesis
Regulation Of Epithelial Cell Proliferation
Regulation Of Neurogenesis
Inner Ear Receptor Cell Stereocilium Organization
Regulation Of Timing Of Neuron Differentiation
Negative Regulation Of Glial Cell Proliferation
Ventricular Septum Morphogenesis
Ureteric Bud Morphogenesis
Labyrinthine Layer Blood Vessel Development
Common Bile Duct Development
Negative Regulation Of Stomach Neuroendocrine Cell Differentiation
Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis
Pharyngeal Arch Artery Morphogenesis
Protein-containing Complex Assembly
Glomerulus Vasculature Development
Comma-shaped Body Morphogenesis
S-shaped Body Morphogenesis
Renal Interstitial Fibroblast Development
Metanephric Nephron Tubule Morphogenesis
Cochlea Development
Establishment Of Epithelial Cell Polarity
Vascular Smooth Muscle Cell Development
Neuronal Stem Cell Population Maintenance
Negative Regulation Of Cell Fate Determination
Negative Regulation Of Pancreatic A Cell Differentiation
Negative Regulation Of Stem Cell Differentiation
Negative Regulation Of Pro-B Cell Differentiation
Negative Regulation Of Forebrain Neuron Differentiation
Autophagosome Assembly
Ubiquitin-dependent Protein Catabolic Process
Macroautophagy
Regulation Of Macroautophagy
Ubiquitin-dependent ERAD Pathway
Regulation Of Protein Ubiquitination
Positive Regulation Of Protein Ubiquitination
Negative Regulation Of Toll-like Receptor 3 Signaling Pathway
Response To Endoplasmic Reticulum Stress
Aggrephagy
Cellular Response To Hypoxia
Autophagosome Maturation
Negative Regulation Of Store-operated Calcium Channel Activity
Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process
Pathways
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
NOTCH1 Intracellular Domain Regulates Transcription
NOTCH2 intracellular domain regulates transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
RUNX2 regulates osteoblast differentiation
RUNX3 regulates NOTCH signaling
RUNX3 regulates NOTCH signaling
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH4 Intracellular Domain Regulates Transcription
Cargo recognition for clathrin-mediated endocytosis
Drugs
Diseases
GWAS
Alcoholic chronic pancreatitis (
28754779
)
Dental caries (decayed, missing and filled teeth) (
31533690
)
Dental caries (decayed, missing and filled tooth surfaces) (
31533690
)
Thyroid stimulating hormone levels (
30367059
)
Metabolite levels (
23823483
)
Interacting Genes
35 interacting genes:
APCS
APH1A
ASGR2
CSNK1E
FANCA
FANCE
FANCF
FANCG
FANCL
FHL1
FOXG1
GAPDH
HDAC6
HES6
HEY1
HEY2
HMGB1
HMGCL
ID1
ID2
ID3
ID4
JAK2
LTBR
NHLH2
NR4A1
NUDT3
PRKCA
PTK2
SIRT1
STAT3
TLE1
TLE2
UBQLN1
YWHAB
164 interacting genes:
ABCC2
ACOT7
ADRM1
AGPAT5
AGR2
AGR3
APP
ASCL1
ATXN3
BPIFA1
C1QA
C1QTNF2
CALU
CCL7
CD47
CD99
CD99L2
CHGB
CHRNA3
CHRNA4
CHRNB4
CLCN2
COL10A1
COL1A2
COLGALT2
COMTD1
COPS4
CSTF2
CSTF2T
CTAG1B
CTAG2
CYB5R1
DEFA6
DNAJB2
DOLK
EFEMP2
EP300
EPS15
ERP27
ETNK1
F8
FAM189A2
FAM86B3P
FAS
FBXO25
FCGR2A
FGF7
FKBP2
FN1
FZD7
GABRA1
GABRA2
GABRA3
GABRA6
GABRB1
GABRB2
GABRB3
GABRD
GHRL
GIT2
GKAP1
GPX3
GRM2
GYPB
HERC3
HES1
HGS
HK2
HSD17B12
HSPA13
IGL
IGLC1
IGLV2-14
IL6ST
IST1
ITPRIPL1
KLHL42
LHX4
LITAF
MANBAL
MAP3K1
MCM7
MIEF1
MIEF2
MLLT6
MTNR1A
MTOR
NAXD
NBL1
NDE1
NEDD8
NGLY1
NLGN3
NME3
NPPA
NPY
NT5C3A
NUP58
P4HB
PARVA
PBXIP1
PIK3IP1
PLAAT3
PNMA1
PPIB
PPIC
PRAP1
PRB1
PRPF40A
PSEN1
PSEN2
PSMD4
PSMD6
PTN
RARA
RASSF5
RIC8A
RNF208
RPN1
RSRC2
RTL8A
RTL8B
RTL8C
SCG2
SCG5
SCMH1
SERPINE1
SERPINI2
SIL1
SLC29A2
SMAD9
SMIM2
SMR3B
SMURF1
SPARC
SRGN
STMN3
SYNJ2BP
TARDBP
TFF1
TICAM1
TLR4
TMCO6
TMEM31
TMEM37
TMEM67
TMUB2
TNFRSF1A
TNFRSF1B
TREX1
TRIM32
TXNDC12
UBB
UBC
UBE2V1
UBE3A
UBQLN4
UBXN1
WBP2
XPO4
ZFAND2B
ZG16
ZG16B
ZNF343
Entrez ID
3280
29979
HPRD ID
00770
05440
Ensembl ID
ENSG00000114315
ENSG00000135018
Uniprot IDs
Q14469
A0A024R258
Q9UMX0
PDB IDs
2MH3
2JY5
2JY6
2KLC
Enriched GO Terms of Interacting Partners
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