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HES1 and HMGB1
Number of citations of the paper that reports this interaction (PubMedID
11748221
)
38
Data Source:
HPRD
(in vitro)
HES1
HMGB1
Description
hes family bHLH transcription factor 1
high mobility group box 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Protein-containing Complex
Nuclear Chromatin
Condensed Chromosome
Extracellular Region
Extracellular Space
Cell
Nucleus
Nucleoplasm
Cytoplasm
Endosome
Endoplasmic Reticulum-Golgi Intermediate Compartment
Cell Surface
Transcriptional Repressor Complex
Secretory Granule Lumen
Alphav-beta3 Integrin-HMGB1 Complex
Ficolin-1-rich Granule Lumen
Molecular Function
RNA Polymerase II Regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA Binding
Protein Binding
Transcription Factor Binding
Protein Homodimerization Activity
Histone Deacetylase Binding
HLH Domain Binding
Sequence-specific DNA Binding
Chaperone Binding
E-box Binding
N-box Binding
Four-way Junction DNA Binding
Bubble DNA Binding
Lipopolysaccharide Binding
Phosphatidylserine Binding
Damaged DNA Binding
Double-stranded DNA Binding
Single-stranded DNA Binding
Transcription Coactivator Activity
RNA Binding
Cytokine Activity
Integrin Binding
Protein Binding
Transcription Factor Binding
DNA Binding, Bending
Lyase Activity
C-X-C Chemokine Binding
Chemoattractant Activity
Transcription Regulatory Region DNA Binding
RAGE Receptor Binding
DNA Polymerase Binding
Repressing Transcription Factor Binding
Supercoiled DNA Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Liver Development
Embryonic Heart Tube Morphogenesis
Outflow Tract Morphogenesis
Regulation Of Secondary Heart Field Cardioblast Proliferation
Ventricular Septum Development
Cell Adhesion
Notch Signaling Pathway
Smoothened Signaling Pathway
Nervous System Development
Positive Regulation Of Cell Proliferation
Anterior/posterior Pattern Specification
Cell Migration
Telencephalon Development
Midbrain-hindbrain Boundary Morphogenesis
Oculomotor Nerve Development
Trochlear Nerve Development
Hindbrain Morphogenesis
Forebrain Radial Glial Cell Differentiation
Adenohypophysis Development
Cell Differentiation
Lung Development
Positive Regulation Of BMP Signaling Pathway
Midbrain Development
Pancreas Development
Somatic Stem Cell Population Maintenance
Ascending Aorta Morphogenesis
Positive Regulation Of T Cell Proliferation
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Positive Regulation Of DNA Binding
Regulation Of Fat Cell Differentiation
Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation
Negative Regulation Of Neuron Differentiation
Positive Regulation Of Notch Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Mitotic Cell Cycle, Embryonic
Lateral Inhibition
Regulation Of JAK-STAT Cascade
Positive Regulation Of JAK-STAT Cascade
Cell Maturation
Thymus Development
Cell Morphogenesis Involved In Neuron Differentiation
Positive Regulation Of Astrocyte Differentiation
Negative Regulation Of Oligodendrocyte Differentiation
Artery Morphogenesis
Regulation Of Epithelial Cell Proliferation
Regulation Of Neurogenesis
Inner Ear Receptor Cell Stereocilium Organization
Regulation Of Timing Of Neuron Differentiation
Negative Regulation Of Glial Cell Proliferation
Ventricular Septum Morphogenesis
Ureteric Bud Morphogenesis
Labyrinthine Layer Blood Vessel Development
Common Bile Duct Development
Negative Regulation Of Stomach Neuroendocrine Cell Differentiation
Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis
Pharyngeal Arch Artery Morphogenesis
Protein-containing Complex Assembly
Glomerulus Vasculature Development
Comma-shaped Body Morphogenesis
S-shaped Body Morphogenesis
Renal Interstitial Fibroblast Development
Metanephric Nephron Tubule Morphogenesis
Cochlea Development
Establishment Of Epithelial Cell Polarity
Vascular Smooth Muscle Cell Development
Neuronal Stem Cell Population Maintenance
Negative Regulation Of Cell Fate Determination
Negative Regulation Of Pancreatic A Cell Differentiation
Negative Regulation Of Stem Cell Differentiation
Negative Regulation Of Pro-B Cell Differentiation
Negative Regulation Of Forebrain Neuron Differentiation
Negative Regulation Of Transcription By RNA Polymerase II
Myeloid Dendritic Cell Activation
Activation Of Innate Immune Response
Toll-like Receptor Signaling Pathway
Dendritic Cell Chemotaxis
Inflammatory Response To Antigenic Stimulus
Regulation Of Tolerance Induction
Regulation Of T Cell Mediated Immune Response To Tumor Cell
DNA Topological Change
Apoptotic DNA Fragmentation
DNA Recombination
Chromatin Remodeling
Chromatin Silencing
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Autophagy
Inflammatory Response
Positive Regulation Of Cytosolic Calcium Ion Concentration
Regulation Of Signaling Receptor Activity
Positive Regulation Of Autophagy
Viral Process
Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly
Neuron Projection Development
Regulation Of Restriction Endodeoxyribonuclease Activity
DNA Geometric Change
Positive Regulation Of Mismatch Repair
Developmental Process
Negative Regulation Of Interferon-gamma Production
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
V(D)J Recombination
Positive Regulation Of Toll-like Receptor 9 Signaling Pathway
T-helper 1 Cell Activation
Positive Regulation Of Activated T Cell Proliferation
Positive Regulation Of Apoptotic Process
Apoptotic Cell Clearance
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Neutrophil Degranulation
Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation
Positive Regulation Of DNA Binding
Positive Regulation Of MAPK Cascade
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Negative Regulation Of Blood Vessel Endothelial Cell Migration
T-helper 1 Cell Differentiation
Innate Immune Response
Positive Regulation Of Innate Immune Response
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of JNK Cascade
Positive Regulation Of Interleukin-1 Secretion
Positive Regulation Of Interleukin-1 Beta Secretion
Positive Chemotaxis
DNA Ligation Involved In DNA Repair
Positive Regulation Of DNA Ligation
Cell Chemotaxis
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Lipopolysaccharide
Positive Regulation Of Monocyte Chemotaxis
Neutrophil Clearance
Positive Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of Interferon-alpha Secretion
Positive Regulation Of Vascular Endothelial Cell Proliferation
Tumor Necrosis Factor Secretion
Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Negative Regulation Of Apoptotic Cell Clearance
Positive Regulation Of Interleukin-6 Secretion
Positive Regulation Of Dendritic Cell Differentiation
Pathways
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
NOTCH1 Intracellular Domain Regulates Transcription
NOTCH2 intracellular domain regulates transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
RUNX2 regulates osteoblast differentiation
RUNX3 regulates NOTCH signaling
RUNX3 regulates NOTCH signaling
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH4 Intracellular Domain Regulates Transcription
Apoptosis induced DNA fragmentation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Regulation of TLR by endogenous ligand
Neutrophil degranulation
Advanced glycosylation endproduct receptor signaling
Advanced glycosylation endproduct receptor signaling
TRAF6 mediated NF-kB activation
Drugs
Ethyl pyruvate
Diseases
GWAS
Alcoholic chronic pancreatitis (
28754779
)
Dental caries (decayed, missing and filled teeth) (
31533690
)
Dental caries (decayed, missing and filled tooth surfaces) (
31533690
)
Thyroid stimulating hormone levels (
30367059
)
Blood osmolality (transformed sodium) (
28360221
)
Carotid plaque burden (
28282560
)
Hippocampal volume (
21116278
)
Mean corpuscular hemoglobin (
27863252
)
Mean corpuscular volume (
27863252
)
Type 2 diabetes (
30297969
)
Urate levels (
31578528
)
Interacting Genes
35 interacting genes:
APCS
APH1A
ASGR2
CSNK1E
FANCA
FANCE
FANCF
FANCG
FANCL
FHL1
FOXG1
GAPDH
HDAC6
HES6
HEY1
HEY2
HMGB1
HMGCL
ID1
ID2
ID3
ID4
JAK2
LTBR
NHLH2
NR4A1
NUDT3
PRKCA
PTK2
SIRT1
STAT3
TLE1
TLE2
UBQLN1
YWHAB
94 interacting genes:
ACBD3
AGER
AGTRAP
AR
ATOH1
C1QBP
C3
CASP3
CCAR1
CDK1
CEBPB
CREBBP
CRMP1
CSNK1A1
CTCF
CTNNBL1
CUX1
DNM2
DNMT1
EIF1
ENAH
EP300
ERF
ERG28
FIP1L1
FOXA3
FOXC1
GTF2A1
HES1
HMGA1
HNRNPK
HOXB1
HOXB3
HOXC6
HOXD10
HOXD11
HOXD3
HOXD8
HOXD9
HPF1
HR
HSPA5
IRF2
KRT7
LRIF1
MECP2
MNT
MT2A
NCAN
NEUROD6
NEXN
NFKB1
NR3C1
PCOLCE
PGR
PLAT
PLG
POU5F1
PPP2R3A
PRKCA
PRKDC
PSEN1
PTPRZ1
RAD23B
RAG1
RASSF4
RB1
RBPJ
RELA
RFX1
RPL29
RPS12
RPS20
SIX5
SOX18
SPINT1
TAF1
TBP
TERF2
TERF2IP
TFE3
TGIF1
TLE1
TLE2
TLE5
TLR2
TLR4
TP53
TP73
UBE2I
UNC119
ZFP36
ZNF24
ZNF428
Entrez ID
3280
3146
HPRD ID
00770
01228
Ensembl ID
ENSG00000114315
ENSG00000189403
Uniprot IDs
Q14469
A0A024RDR0
P09429
PDB IDs
2MH3
2LY4
2RTU
2YRQ
6CG0
6CIJ
6CIK
6CIL
6CIM
Enriched GO Terms of Interacting Partners
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