APBA1 and CCS

Number of citations of the paper that reports this interaction (PubMedID 11115513)
7

Data Source:
HPRD (in vitro, in vivo)

		APBA1	CCS
Description		amyloid beta precursor protein binding family A member 1	copper chaperone for superoxide dismutase
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Synaptic Vesicle Dendritic Spine Synapse Perinuclear Region Of Cytoplasm Presynaptic Active Zone Membrane Schaffer Collateral - CA1 Synapse Glutamatergic Synapse	Nucleus Cytoplasm Cytosol
	Molecular Function	Amyloid-beta Binding Protein Binding	Superoxide Dismutase Activity Copper Ion Binding Protein Binding Protein Disulfide Oxidoreductase Activity Superoxide Dismutase Copper Chaperone Activity Cadherin Binding
	Biological Process	In Utero Embryonic Development Intracellular Protein Transport Cell Adhesion Chemical Synaptic Transmission Neurotransmitter Secretion Nervous System Development Locomotory Behavior Axo-dendritic Transport Regulation Of Gene Expression Glutamate Secretion Gamma-aminobutyric Acid Secretion Multicellular Organism Growth Protein-containing Complex Assembly Regulation Of Synaptic Vesicle Exocytosis	Superoxide Metabolic Process Protein Maturation By Copper Ion Transfer Removal Of Superoxide Radicals Metal Ion Transport Cellular Response To Oxidative Stress Positive Regulation Of Oxidoreductase Activity Oxidation-reduction Process
Pathways		Dopamine Neurotransmitter Release Cycle Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors	Detoxification of Reactive Oxygen Species Detoxification of Reactive Oxygen Species
Drugs			Zinc
Diseases
GWAS		Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Extremely high intelligence ( 29520040) Intelligence ( 28530673) Intelligence (MTAG) ( 29326435) Itch intensity from mosquito bite adjusted by bite size ( 28199695)	Bipolar disorder ( 21926972)
Interacting Genes		17 interacting genes: APP ARF3 ARF4 CACNA1B CASK CCS CNTNAP3 CNTNAP4 HTR2C KCNJ12 KIF17 LIN7B NOTCH1 NRXN1 PSEN1 STX1A STXBP1	3 interacting genes: APBA1 SOD1 YWHAG
Entrez ID		320	9973
HPRD ID		03879	04841
Ensembl ID		ENSG00000107282	ENSG00000173992
Uniprot IDs		Q02410	O14618
PDB IDs		1AQC 1U37 1U38 1U39 1U3B 1X11 1X45 1Y7N	1DO5 2CRL 2RSQ 6FN8 6FOL 6FON 6FP6
Enriched GO Terms of Interacting Partners?
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