APBA1 and CACNA1B

Number of citations of the paper that reports this interaction (PubMedID 10455105)
82

Data Source:
HPRD (two hybrid, in vivo)

		APBA1	CACNA1B
Description		amyloid beta precursor protein binding family A member 1	calcium voltage-gated channel subunit alpha1 B
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Synaptic Vesicle Dendritic Spine Synapse Perinuclear Region Of Cytoplasm Presynaptic Active Zone Membrane Schaffer Collateral - CA1 Synapse Glutamatergic Synapse	Plasma Membrane Voltage-gated Calcium Channel Complex Dendrite Neuronal Cell Body Presynapse
	Molecular Function	Amyloid-beta Binding Protein Binding	Amyloid-beta Binding Voltage-gated Calcium Channel Activity Calcium Ion Binding Protein Binding ATP Binding Protein C-terminus Binding High Voltage-gated Calcium Channel Activity
	Biological Process	In Utero Embryonic Development Intracellular Protein Transport Cell Adhesion Chemical Synaptic Transmission Neurotransmitter Secretion Nervous System Development Locomotory Behavior Axo-dendritic Transport Regulation Of Gene Expression Glutamate Secretion Gamma-aminobutyric Acid Secretion Multicellular Organism Growth Protein-containing Complex Assembly Regulation Of Synaptic Vesicle Exocytosis	Calcium Ion Transport Chemical Synaptic Transmission Neurotransmitter Secretion Locomotory Behavior Regulation Of Heart Contraction Regulation Of Blood Pressure Regulation Of Ion Transmembrane Transport Response To Pain Modulation Of Chemical Synaptic Transmission Membrane Depolarization Regulation Of Calcium Ion Transport Calcium Ion Import Calcium Ion Transmembrane Transport Response To Amyloid-beta
Pathways		Dopamine Neurotransmitter Release Cycle Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors	Presynaptic depolarization and calcium channel opening
Drugs			Amlodipine Spironolactone Verapamil Gabapentin Levetiracetam Seletracetam Contulakin-G Agmatine
Diseases
GWAS		Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Extremely high intelligence ( 29520040) Intelligence ( 28530673) Intelligence (MTAG) ( 29326435) Itch intensity from mosquito bite adjusted by bite size ( 28199695)	Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 25987655) Bipolar disorder ( 31043756) Body mass index ( 28552196) Weight ( 28552196)
Interacting Genes		17 interacting genes: APP ARF3 ARF4 CACNA1B CASK CCS CNTNAP3 CNTNAP4 HTR2C KCNJ12 KIF17 LIN7B NOTCH1 NRXN1 PSEN1 STX1A STXBP1	9 interacting genes: APBA1 CACNB3 GNAO1 GNB1 PDLIM5 PPM1A RGS12 RIMS1 RXRB
Entrez ID		320	774
HPRD ID		03879	03005
Ensembl ID		ENSG00000107282	ENSG00000148408
Uniprot IDs		Q02410	Q00975
PDB IDs		1AQC 1U37 1U38 1U39 1U3B 1X11 1X45 1Y7N	2LCM
Enriched GO Terms of Interacting Partners?
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