HMGCL and HSD17B10

Number of citations of the paper that reports this interaction (PubMedID 22496890)
5

Data Source:
BioGRID (two hybrid)

		HMGCL	HSD17B10
Description		3-hydroxy-3-methylglutaryl-CoA lyase	hydroxysteroid 17-beta dehydrogenase 10
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Peroxisome Peroxisomal Matrix Cytosol Protein-containing Complex	Cytoplasm Mitochondrion Mitochondrial Matrix Plasma Membrane Mitochondrial Ribonuclease P Complex
	Molecular Function	Fatty-acyl-CoA Binding Magnesium Ion Binding Hydroxymethylglutaryl-CoA Lyase Activity Structural Molecule Activity Manganese Ion Binding Carboxylic Acid Binding Metal Ion Binding	TRNA Binding RNA Binding 3-hydroxyacyl-CoA Dehydrogenase Activity Protein Binding Cholate 7-alpha-dehydrogenase Activity Testosterone Dehydrogenase [NAD(P)] Activity Dihydrotestosterone 17-beta-dehydrogenase Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity
	Biological Process	Liver Development Leucine Catabolic Process Protein Targeting To Peroxisome Lipid Metabolic Process Acyl-CoA Metabolic Process Mitochondrion Organization Response To Nutrient Response To Starvation Ketone Body Biosynthetic Process Response To Fatty Acid	Lipid Metabolic Process Mitochondrion Organization Branched-chain Amino Acid Catabolic Process Protein Homotetramerization Oxidation-reduction Process Mitochondrial TRNA Methylation Mitochondrial TRNA Processing Mitochondrial TRNA 5'-end Processing Mitochondrial TRNA 3'-end Processing
Pathways		Synthesis of Ketone Bodies Peroxisomal protein import Peroxisomal protein import	tRNA processing in the mitochondrion tRNA modification in the mitochondrion Branched-chain amino acid catabolism rRNA processing in the mitochondrion
Drugs		3-hydroxyglutaric acid	NADH 1-Azepan-1-Yl-2-Phenyl-2-(4-Thioxo-1,4-Dihydro-Pyrazolo[3,4-D]Pyrimidin-5-Yl)Ethanone Adduct
Diseases		3-Hydroxy-3-methylglutaryl-CoA lyase deficiency	2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency; HSD10 deficiency Non-syndromic X-linked mental retardation Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
GWAS		High light scatter reticulocyte count ( 27863252) Immature fraction of reticulocytes ( 27863252) Reticulocyte fraction of red cells ( 27863252)	Bipolar disorder ( 31043756) Body mass index ( 28892062)
Interacting Genes		9 interacting genes: ADAMTS10 ARL6IP1 DNAJA1 GTF2B HES1 HSD17B10 MS4A7 PEX5 RNF126	31 interacting genes: ALDH3B1 ALDOA APP ATP5F1A CHD3 CPS1 CS ETFDH FAF1 GLUD1 GLUL HADHA HADHB HMGCL HMGCS2 HTRA2 MDH1 OGDH PDHA1 PDHB PDHX PINK1 PRKN PYGL TOMM20 TOMM22 TOMM40 TRAF3IP2 TRAF5 TRAF6 UBE2D1
Entrez ID		3155	3028
HPRD ID		02003	02223
Ensembl ID		ENSG00000117305	ENSG00000072506
Uniprot IDs		P35914	A0A0S2Z410 Q99714
PDB IDs		2CW6 3MP3 3MP4 3MP5	1F67 1SO8 1U7T 2O23
Enriched GO Terms of Interacting Partners?
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