GTF2I and PJA1

Number of citations of the paper that reports this interaction (PubMedID 21461837)
6

Data Source:
BioGRID (enzymatic study)

		GTF2I	PJA1
Description		general transcription factor IIi	praja ring finger ubiquitin ligase 1
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GO Annotations	Cellular Component	Cell Nucleus Nucleoplasm Cytoplasm Membrane	Cytoplasm
	Molecular Function	DNA Binding DNA-binding Transcription Factor Activity Protein Binding	Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Regulation Of Transcription, DNA-templated Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Negative Regulation Of Angiogenesis Negative Regulation Of Cytosolic Calcium Ion Concentration	Protein Ubiquitination Protein Catabolic Process
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Atrial fibrillation ( 30061737 29892015) C-reactive protein levels ( 30388399) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Diastolic blood pressure ( 30224653) Heel bone mineral density ( 30598549) Menarche (age at onset) ( 25231870) SjÃ¶gren's syndrome ( 24097066 27503288) Systemic lupus erythematosus ( 28714469)	Birth weight ( 31043758) Body mass index ( 29273807) Schizophrenia ( 25056061 29483656)
Interacting Genes		39 interacting genes: AP2B1 AP4S1 ATF6 BCL2L11 BTK C4BPA CALM1 DNMT3L DPY30 GCC1 HDAC3 JAK2 LSM8 MAP3K3 MAPK12 MAPK3 MTUS2 MYC NFKB2 PIAS2 PJA1 POU2AF1 PRKG1 PRRX1 SLU7 SMAD2 SNRPN SRC SRF STAT1 STAT3 TAB2 TRAF6 UBC UBE2I USF1 YY1 ZBTB17 ZMYM3	64 interacting genes: ABR ASCC2 ATP5F1C ATXN3 ATXN3L CAMK1G CDK16 COASY CSAG3 DDX54 EED ELAC1 ESPL1 EZH2 FGF12 GATD3A GLO1 GSR GTF2I HNRNPC HNRNPL HOMER2 JOSD1 KIF22 LCP2 LRG1 MAGEB4 MAGED1 MDM2 METAP2 NAGK NATD1 NDN OTUB1 OTUB2 PCCA PFKFB4 PHGDH PIP4K2C RIBC2 SPTBN1 STAC STAM STAMBP SUZ12 TAF9 TK1 TMEM214 TSSK3 TXNDC5 UBE2D2 UBE2D3 UBE2E3 UBE2K UBE2L3 UBE2U UCHL3 UCHL5 USP20 USP28 USP5 USP51 USP8 ZNF440
Entrez ID		2969	64219
HPRD ID		03399	02335
Ensembl ID		ENSG00000263001	ENSG00000181191
Uniprot IDs		A8K9W7 P78347 Q499G6 X5D2J9 X5D939 X5DNP5 X5DR09	Q8NG27
PDB IDs		2D9B 2DN4 2ED2 2EJE	2L0B
Enriched GO Terms of Interacting Partners?
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