GTF2I and POU2AF1

Number of citations of the paper that reports this interaction (PubMedID 21549311)
25

Data Source:
BioGRID (pull down, affinity chromatography technology)

		GTF2I	POU2AF1
Description		general transcription factor IIi	POU class 2 homeobox associating factor 1
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GO Annotations	Cellular Component	Cell Nucleus Nucleoplasm Cytoplasm Membrane	RNA Polymerase II Transcription Factor Complex
	Molecular Function	DNA Binding DNA-binding Transcription Factor Activity Protein Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding
	Biological Process	Regulation Of Transcription, DNA-templated Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Negative Regulation Of Angiogenesis Negative Regulation Of Cytosolic Calcium Ion Concentration	Transcription By RNA Polymerase II Humoral Immune Response Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases
GWAS		Atrial fibrillation ( 30061737 29892015) C-reactive protein levels ( 30388399) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Diastolic blood pressure ( 30224653) Heel bone mineral density ( 30598549) Menarche (age at onset) ( 25231870) SjÃ¶gren's syndrome ( 24097066 27503288) Systemic lupus erythematosus ( 28714469)	Celiac disease ( 22057235) Corneal structure ( 23291589) Diverticular disease ( 30177863) Hodgkin's lymphoma ( 30194254) Low urine pH ( 30476138) Multiple sclerosis ( 31604244) Primary biliary cholangitis ( 23000144 28062665) Serum urea levels ( 30808845) Urine pH measurement ( 30476138)
Interacting Genes		39 interacting genes: AP2B1 AP4S1 ATF6 BCL2L11 BTK C4BPA CALM1 DNMT3L DPY30 GCC1 HDAC3 JAK2 LSM8 MAP3K3 MAPK12 MAPK3 MTUS2 MYC NFKB2 PIAS2 PJA1 POU2AF1 PRKG1 PRRX1 SLU7 SMAD2 SNRPN SRC SRF STAT1 STAT3 TAB2 TRAF6 UBC UBE2I USF1 YY1 ZBTB17 ZMYM3	19 interacting genes: GATA2 GCC2 GTF2H1 GTF2I MSX2 NAB1 NOTCH1 PAX8 POU2F1 POU2F2 PTPN11 RHOXF2 SIAH1 SIAH2 SLC22A1 SLC22A2 SMAD2 SUB1 SYK
Entrez ID		2969	5450
HPRD ID		03399	03126
Ensembl ID		ENSG00000263001	ENSG00000110777
Uniprot IDs		A8K9W7 P78347 Q499G6 X5D2J9 X5D939 X5DNP5 X5DR09	Q16633
PDB IDs		2D9B 2DN4 2ED2 2EJE	1CQT
Enriched GO Terms of Interacting Partners?
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