PJA1 and HOMER2

Number of citations of the paper that reports this interaction (PubMedID 21461837)
6

Data Source:
BioGRID (enzymatic study)

		PJA1	HOMER2
Description		praja ring finger ubiquitin ligase 1	homer scaffold protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Cell Junction Dendrite Stereocilium Tip Neuron Projection Neuronal Cell Body Apical Part Of Cell Glutamatergic Synapse
	Molecular Function	Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Actin Binding Protein Binding Protein Domain Specific Binding GKAP/Homer Scaffold Activity G Protein-coupled Glutamate Receptor Binding Identical Protein Binding Protein-containing Complex Binding
	Biological Process	Protein Ubiquitination Protein Catabolic Process	G Protein-coupled Glutamate Receptor Signaling Pathway Sensory Perception Of Sound Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Signal Transduction Negative Regulation Of Interleukin-2 Production Calcium-mediated Signaling Using Intracellular Calcium Source Behavioral Response To Cocaine Chemical Homeostasis Within A Tissue Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Store-operated Calcium Entry
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS		Birth weight ( 31043758) Body mass index ( 29273807) Schizophrenia ( 25056061 29483656)	Tourette syndrome ( 30818990)
Interacting Genes		64 interacting genes: ABR ASCC2 ATP5F1C ATXN3 ATXN3L CAMK1G CDK16 COASY CSAG3 DDX54 EED ELAC1 ESPL1 EZH2 FGF12 GATD3A GLO1 GSR GTF2I HNRNPC HNRNPL HOMER2 JOSD1 KIF22 LCP2 LRG1 MAGEB4 MAGED1 MDM2 METAP2 NAGK NATD1 NDN OTUB1 OTUB2 PCCA PFKFB4 PHGDH PIP4K2C RIBC2 SPTBN1 STAC STAM STAMBP SUZ12 TAF9 TK1 TMEM214 TSSK3 TXNDC5 UBE2D2 UBE2D3 UBE2E3 UBE2K UBE2L3 UBE2U UCHL3 UCHL5 USP20 USP28 USP5 USP51 USP8 ZNF440	12 interacting genes: AGAP2 APP DBN1 GRM1 ITPR1 KPNA2 LZTS2 PJA1 RYR1 SMURF1 UBXN1 VKORC1
Entrez ID		64219	9455
HPRD ID		02335	07269
Ensembl ID		ENSG00000181191	ENSG00000103942
Uniprot IDs		Q8NG27	Q9NSB8
PDB IDs		2L0B
Enriched GO Terms of Interacting Partners?
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