GRIN2C and PATJ

Number of citations of the paper that reports this interaction (PubMedID 9647694)
28

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		GRIN2C	PATJ
Description		glutamate ionotropic receptor NMDA type subunit 2C	PATJ crumbs cell polarity complex component
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cell Plasma Membrane Integral Component Of Plasma Membrane NMDA Selective Glutamate Receptor Complex Cell Junction Postsynaptic Membrane Postsynaptic Density Membrane Glutamatergic Synapse	Centrosome Cytosol Plasma Membrane Bicellular Tight Junction Apical Plasma Membrane Cell Junction Centriolar Satellite Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	NMDA Glutamate Receptor Activity Protein Binding Glutamate Receptor Activity Ligand-gated Ion Channel Activity Glutamate-gated Calcium Ion Channel Activity Signaling Receptor Activity Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Protein Binding
	Biological Process	Glutamate Receptor Signaling Pathway Brain Development Response To Wounding Calcium-mediated Signaling Directional Locomotion Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Negative Regulation Of Protein Catabolic Process Regulation Of Synaptic Plasticity Modulation Of Chemical Synaptic Transmission Neuromuscular Process Controlling Balance Excitatory Postsynaptic Potential Long-term Synaptic Potentiation Calcium Ion Transmembrane Import Into Cytosol Excitatory Chemical Synaptic Transmission Protein Localization To Postsynaptic Membrane	Intracellular Signal Transduction Bicellular Tight Junction Assembly
Pathways		Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs		Glutamic Acid Glycine Atomoxetine Pentobarbital Secobarbital Pethidine Acamprosate Gabapentin Phenobarbital Tenocyclidine Prasterone Milnacipran Ketobemidone Gavestinel Magnesium acetate tetrahydrate Magnesium carbonate Fluciclovine (18F)
Diseases
GWAS		Congenital heart disease (maternal effect) ( 28468790)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30582445) Excessive daytime sleepiness ( 27992416) Sleep traits (multi-trait analysis) ( 27992416) Type 2 diabetes ( 30297969)
Interacting Genes		6 interacting genes: DLG3 DLG4 DLGAP1 ERBIN IL16 PATJ	28 interacting genes: ADGRB1 ASIC3 CACNG2 CLDN1 CNKSR2 CRB3 CRIPT DDX18 GLS2 GRIN2A GRIN2B GRIN2C GRIN2D KCNA4 KCNJ10 KCNJ15 KCNJ2 KIF1B MAPK12 MPP5 NLGN2 NRXN2 PARD3 PAX6 PRDM16 SCN4A SCN5A TJP3
Entrez ID		2905	10207
HPRD ID		00699	04434
Ensembl ID		ENSG00000161509	ENSG00000132849
Uniprot IDs		H0Y2V8 O15398 Q14957 Q8IW23
PDB IDs
Enriched GO Terms of Interacting Partners?
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