GRN and ARFGAP1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, two hybrid)

		GRN	ARFGAP1
Description		granulin precursor	ADP ribosylation factor GTPase activating protein 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Lysosome Lysosomal Membrane Endosome Late Endosome Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Plasma Membrane Membrane Azurophil Granule Lumen Extracellular Exosome	Golgi Membrane Cytosol Postsynaptic Density Synapse
	Molecular Function	RNA Binding Cytokine Activity Protein Binding Growth Factor Activity Chaperone Binding	GTPase Activator Activity Protein Binding Metal Ion Binding
	Biological Process	Astrocyte Activation Involved In Immune Response Microglial Cell Activation Involved In Immune Response Lysosome Organization Lysosomal Transport Lysosomal Lumen Acidification Signal Transduction Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Cell Migration Neutrophil Degranulation Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Angiogenesis Positive Regulation Of Axon Regeneration Positive Regulation Of Epithelial Cell Proliferation Regulation Of Inflammatory Response Protein Stabilization Regulation Of Nervous System Development Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Positive Regulation Of Inflammatory Response To Wounding Positive Regulation Of Defense Response To Bacterium Negative Regulation Of Neutrophil Activation Positive Regulation Of Protein Folding Negative Regulation Of Microglial Cell Activation Positive Regulation Of Aspartic-type Peptidase Activity Positive Regulation Of Lysosome Organization	ER To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To ER Protein Transport Regulation Of Endocytosis Regulation Of ARF Protein Signal Transduction IRE1-mediated Unfolded Protein Response Positive Regulation Of GTPase Activity
Pathways		Neutrophil degranulation	XBP1(S) activates chaperone genes COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic Clathrin-mediated endocytosis
Drugs
Diseases		Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)
GWAS		Blood protein levels ( 30072576 29875488) Intracranial volume ( 22504418) Progranulin levels ( 29186428) Subcortical brain region volumes ( 25607358)
Interacting Genes		38 interacting genes: ARFGAP1 ATN1 ATXN7 CACNA1A CCDC33 CCNG1 CCNT1 CDK9 CRKL CRY1 DLK1 DLX2 ELANE FAM131C FANCL FRAT1 GFI1B GLRX3 HK3 HOXA1 HSPG2 KRT18 KRTAP10-7 KRTAP26-1 NLK OTX1 PIK3R2 POT1 PRKAB2 RAC1 SGTA SLPI SMAD9 SPRY2 TAT TGM2 TOP3B YY1	34 interacting genes: APOB APOC3 APOE APP ARF1 ASB10 COPA COPS5 CSNK1D CYTH2 FOS GABARAPL2 GGCX GRN HRAS KDELR1 KRTAP10-9 KRTAP3-2 KRTAP9-2 LRRK2 MAP1LC3B MED27 PRKACB RAB23 RABGAP1L RASIP1 REEP5 RFC3 RGS2 RPL11 SMN1 TK1 TMED2 TRIM23
Entrez ID		2896	55738
HPRD ID		00733	06443
Ensembl ID		ENSG00000030582	ENSG00000101199
Uniprot IDs		P28799	Q53F62 Q8N6T3
PDB IDs		1G26 2JYE 2JYT 2JYU 2JYV	3DWD 3O47
Enriched GO Terms of Interacting Partners?
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