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GRN and HK3
Number of citations of the paper that reports this interaction (PubMedID
11068878
)
5
Data Source:
HPRD
(two hybrid, in vivo, in vitro)
GRN
HK3
Description
granulin precursor
hexokinase 3
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Cell
Lysosome
Lysosomal Membrane
Endosome
Late Endosome
Endoplasmic Reticulum
Golgi Apparatus
Trans-Golgi Network
Plasma Membrane
Membrane
Azurophil Granule Lumen
Extracellular Exosome
Extracellular Region
Cell
Cytosol
Secretory Granule Lumen
Ficolin-1-rich Granule Lumen
Molecular Function
RNA Binding
Cytokine Activity
Protein Binding
Growth Factor Activity
Chaperone Binding
Glucokinase Activity
Hexokinase Activity
ATP Binding
Glucose Binding
Fructokinase Activity
Mannokinase Activity
Biological Process
Astrocyte Activation Involved In Immune Response
Microglial Cell Activation Involved In Immune Response
Lysosome Organization
Lysosomal Transport
Lysosomal Lumen Acidification
Signal Transduction
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Cell Migration
Neutrophil Degranulation
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Neuron Apoptotic Process
Positive Regulation Of Angiogenesis
Positive Regulation Of Axon Regeneration
Positive Regulation Of Epithelial Cell Proliferation
Regulation Of Inflammatory Response
Protein Stabilization
Regulation Of Nervous System Development
Negative Regulation Of Respiratory Burst Involved In Inflammatory Response
Positive Regulation Of Inflammatory Response To Wounding
Positive Regulation Of Defense Response To Bacterium
Negative Regulation Of Neutrophil Activation
Positive Regulation Of Protein Folding
Negative Regulation Of Microglial Cell Activation
Positive Regulation Of Aspartic-type Peptidase Activity
Positive Regulation Of Lysosome Organization
Cellular Glucose Homeostasis
Fructose 6-phosphate Metabolic Process
Glycolytic Process
Neutrophil Degranulation
Carbohydrate Phosphorylation
Glucose 6-phosphate Metabolic Process
Canonical Glycolysis
Pathways
Neutrophil degranulation
Neutrophil degranulation
Glycolysis
Drugs
Diseases
Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)
GWAS
Blood protein levels (
30072576
29875488
)
Intracranial volume (
22504418
)
Progranulin levels (
29186428
)
Subcortical brain region volumes (
25607358
)
Uterine fibroids (
30194396
)
Waist-to-hip ratio adjusted for BMI (
26426971
)
Waist-to-hip ratio adjusted for BMI (age <50) (
26426971
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Interacting Genes
38 interacting genes:
ARFGAP1
ATN1
ATXN7
CACNA1A
CCDC33
CCNG1
CCNT1
CDK9
CRKL
CRY1
DLK1
DLX2
ELANE
FAM131C
FANCL
FRAT1
GFI1B
GLRX3
HK3
HOXA1
HSPG2
KRT18
KRTAP10-7
KRTAP26-1
NLK
OTX1
PIK3R2
POT1
PRKAB2
RAC1
SGTA
SLPI
SMAD9
SPRY2
TAT
TGM2
TOP3B
YY1
10 interacting genes:
ATF4
GRN
HPGDS
IGFBP4
LEP
MITF
PPP2CB
PTGDS
STC2
ZBTB17
Entrez ID
2896
3101
HPRD ID
00733
00806
Ensembl ID
ENSG00000030582
ENSG00000160883
Uniprot IDs
P28799
A0A024R7R1
P52790
PDB IDs
1G26
2JYE
2JYT
2JYU
2JYV
3HM8
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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