ARFGAP1 and GGCX

		ARFGAP1	GGCX
Description		ADP ribosylation factor GTPase activating protein 1	gamma-glutamyl carboxylase
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytosol Postsynaptic Density Synapse	Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane
	Molecular Function	GTPase Activator Activity Protein Binding Metal Ion Binding	Gamma-glutamyl Carboxylase Activity Vitamin Binding
	Biological Process	ER To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To ER Protein Transport Regulation Of Endocytosis Regulation Of ARF Protein Signal Transduction IRE1-mediated Unfolded Protein Response Positive Regulation Of GTPase Activity	Cellular Protein Modification Process Blood Coagulation Peptidyl-glutamic Acid Carboxylation
Pathways		XBP1(S) activates chaperone genes COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic Clathrin-mediated endocytosis	Gamma-carboxylation of protein precursors Gamma-carboxylation of protein precursors
Drugs			Coagulation factor VIIa Recombinant Human Drotrecogin alfa Coagulation Factor IX (Recombinant) Glutamic Acid Menadione Phylloquinone Anisindione Coagulation Factor IX Human
Diseases			Pseudoxanthoma elasticum, including: Pseudoxanthoma elasticum (PXE); Pseudoxanthoma elasticum-like disorder with multiple coagulation factor deficiency Combined deficiency of vitamin K-dependent clotting factors (VKCFD)
GWAS			Coronary artery disease ( 29212778 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Myocardial infarction ( 26343387) Prostate cancer ( 21743467)
Interacting Genes		34 interacting genes: APOB APOC3 APOE APP ARF1 ASB10 COPA COPS5 CSNK1D CYTH2 FOS GABARAPL2 GGCX GRN HRAS KDELR1 KRTAP10-9 KRTAP3-2 KRTAP9-2 LRRK2 MAP1LC3B MED27 PRKACB RAB23 RABGAP1L RASIP1 REEP5 RFC3 RGS2 RPL11 SMN1 TK1 TMED2 TRIM23	14 interacting genes: ARFGAP1 ATP2C1 BGLAP CD8A F10 F2 F7 F9 FXN PDCD5 PPM1G PROC SRPK2 ST3GAL4
Entrez ID		55738	2677
HPRD ID		06443	00665
Ensembl ID		ENSG00000101199	ENSG00000115486
Uniprot IDs		Q53F62 Q8N6T3	P38435
PDB IDs		3DWD 3O47
Enriched GO Terms of Interacting Partners?
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