GLUD1 and HSD17B10

Number of citations of the paper that reports this interaction (PubMedID 22496890)
5

Data Source:
BioGRID (two hybrid)

		GLUD1	HSD17B10
Description		glutamate dehydrogenase 1	hydroxysteroid 17-beta dehydrogenase 10
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix	Cytoplasm Mitochondrion Mitochondrial Matrix Plasma Membrane Mitochondrial Ribonuclease P Complex
	Molecular Function	Glutamate Dehydrogenase (NAD+) Activity Glutamate Dehydrogenase [NAD(P)+] Activity Protein Binding ATP Binding GTP Binding Identical Protein Binding ADP Binding NAD+ Binding Leucine Binding	TRNA Binding RNA Binding 3-hydroxyacyl-CoA Dehydrogenase Activity Protein Binding Cholate 7-alpha-dehydrogenase Activity Testosterone Dehydrogenase [NAD(P)] Activity Dihydrotestosterone 17-beta-dehydrogenase Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity
	Biological Process	Glutamate Biosynthetic Process Glutamate Catabolic Process Glutamine Metabolic Process Cellular Amino Acid Biosynthetic Process Substantia Nigra Development Positive Regulation Of Insulin Secretion Oxidation-reduction Process Tricarboxylic Acid Metabolic Process	Lipid Metabolic Process Mitochondrion Organization Branched-chain Amino Acid Catabolic Process Protein Homotetramerization Oxidation-reduction Process Mitochondrial TRNA Methylation Mitochondrial TRNA Processing Mitochondrial TRNA 5'-end Processing Mitochondrial TRNA 3'-end Processing
Pathways		Transcriptional activation of mitochondrial biogenesis Glutamate and glutamine metabolism	tRNA processing in the mitochondrion tRNA modification in the mitochondrion Branched-chain amino acid catabolism rRNA processing in the mitochondrion
Drugs		Glutamic Acid NADH Hexachlorophene Guanosine-5'-Triphosphate Aluminum chloride	NADH 1-Azepan-1-Yl-2-Phenyl-2-(4-Thioxo-1,4-Dihydro-Pyrazolo[3,4-D]Pyrimidin-5-Yl)Ethanone Adduct
Diseases			2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency; HSD10 deficiency Non-syndromic X-linked mental retardation Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
GWAS			Bipolar disorder ( 31043756) Body mass index ( 28892062)
Interacting Genes		12 interacting genes: ASGR2 CRP DYNLL1 GOT2 HPX HSD17B10 LSM1 NR4A1 ORM1 SEC62 STAT5A VTN	31 interacting genes: ALDH3B1 ALDOA APP ATP5F1A CHD3 CPS1 CS ETFDH FAF1 GLUD1 GLUL HADHA HADHB HMGCL HMGCS2 HTRA2 MDH1 OGDH PDHA1 PDHB PDHX PINK1 PRKN PYGL TOMM20 TOMM22 TOMM40 TRAF3IP2 TRAF5 TRAF6 UBE2D1
Entrez ID		2746	3028
HPRD ID		11748	02223
Ensembl ID		ENSG00000148672	ENSG00000072506
Uniprot IDs		E9KL48 P00367	A0A0S2Z410 Q99714
PDB IDs		1L1F 1NR1 6DQG	1F67 1SO8 1U7T 2O23
Enriched GO Terms of Interacting Partners?
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