IL37 and IL18R1

Number of citations of the paper that reports this interaction (PubMedID 12096920)
80

Data Source:
HPRD (in vitro)

		IL37	IL18R1
Description		interleukin 37	interleukin 18 receptor 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Cytosol Intracellular Membrane-bounded Organelle	Plasma Membrane Interleukin-18 Receptor Complex
	Molecular Function	Cytokine Activity Interleukin-1 Receptor Binding	Interleukin-1 Receptor Activity Protein Binding Signaling Receptor Activity Interleukin-18 Binding Interleukin-18 Receptor Activity NAD(P)+ Nucleosidase Activity NAD+ Nucleotidase, Cyclic ADP-ribose Generating
	Biological Process	Inflammatory Response To Antigenic Stimulus Inflammatory Response Immune Response Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Negative Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Interleukin-6 Biosynthetic Process Regulation Of Inflammatory Response Cellular Response To Lipopolysaccharide Cellular Response To Cytokine Stimulus Negative Regulation Of Interleukin-6 Secretion Negative Regulation Of Tumor Necrosis Factor Secretion	Inflammatory Response Immune Response Signal Transduction Natural Killer Cell Activation Positive Regulation Of Interferon-gamma Production Interleukin-18-mediated Signaling Pathway T-helper 1 Cell Differentiation Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Cytokine Stimulus Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of T-helper 1 Cell Cytokine Production
Pathways		Interleukin-37 signaling Interleukin-18 signaling	Interleukin-37 signaling Interleukin-18 signaling
Drugs
Diseases
GWAS		Dysmenorrheic pain severity ( 29855537) Menstruation quality of life impact (dysmenorrhea) ( 29855537) Pain medicine use during menstruation ( 29855537) Pulmonary function ( 23932459) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy) ( 24554482)	Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 31361310) Allergic sensitization ( 23817571) Asthma ( 23028483 31361310 30929738 20860503 31619474 26620591 29273806 22561531) Asthma (adult onset) ( 31036433 30929738) Asthma (childhood onset) ( 31036433 30929738 29273806) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 23042114 26482879) Atypical femoral fracture in phosphonate treatment ( 31006051) Bisphosphonate-associated atypical femoral fracture ( 31006051) Blood protein levels ( 30072576 29875488 28240269) Celiac disease ( 20190752 18311140) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 21102463) Delirium ( 29631748) Eczema ( 31361310) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Inflammatory bowel disease ( 28067908 23128233) Leprosy ( 25642632) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Nasal polyps ( 30643255) Neutrophil percentage of granulocytes ( 27863252) Pediatric autoimmune diseases ( 26301688) Polymyositis ( 26362759) Primary biliary cholangitis ( 26394269) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		5 interacting genes: CASP1 CASP4 IL18BP IL18R1 SMAD3	5 interacting genes: AKAP8L CD48 IL18 IL1RAP IL37
Entrez ID		27178	8809
HPRD ID		05695	05138
Ensembl ID		ENSG00000125571	ENSG00000115604
Uniprot IDs		Q9NZH6	Q13478
PDB IDs		5HN1 6NCU	3WO3 3WO4 4R6U
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?