IL37 and IL18BP

Number of citations of the paper that reports this interaction (PubMedID 12381835)
73

Data Source:
HPRD (in vitro)

		IL37	IL18BP
Description		interleukin 37	interleukin 18 binding protein
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Cytosol Intracellular Membrane-bounded Organelle	Extracellular Region Extracellular Space Extracellular Exosome
	Molecular Function	Cytokine Activity Interleukin-1 Receptor Binding	Interleukin-18 Binding Receptor Antagonist Activity
	Biological Process	Inflammatory Response To Antigenic Stimulus Inflammatory Response Immune Response Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Negative Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Interleukin-6 Biosynthetic Process Regulation Of Inflammatory Response Cellular Response To Lipopolysaccharide Cellular Response To Cytokine Stimulus Negative Regulation Of Interleukin-6 Secretion Negative Regulation Of Tumor Necrosis Factor Secretion	Interleukin-18-mediated Signaling Pathway T-helper 1 Type Immune Response Cellular Response To Cytokine Stimulus Negative Regulation Of Signaling Receptor Activity
Pathways		Interleukin-37 signaling Interleukin-18 signaling	Interleukin-37 signaling Interleukin-18 signaling
Drugs
Diseases
GWAS		Dysmenorrheic pain severity ( 29855537) Menstruation quality of life impact (dysmenorrhea) ( 29855537) Pain medicine use during menstruation ( 29855537) Pulmonary function ( 23932459) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy) ( 24554482)
Interacting Genes		5 interacting genes: CASP1 CASP4 IL18BP IL18R1 SMAD3	2 interacting genes: IL18 IL37
Entrez ID		27178	10068
HPRD ID		05695	04984
Ensembl ID		ENSG00000125571	ENSG00000137496
Uniprot IDs		Q9NZH6	A0A024R5G2 A0A024R5I1 A0A024R5M7 G3V1C5 O95998
PDB IDs		5HN1 6NCU
Enriched GO Terms of Interacting Partners?
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