GLA and PDE6B

		GLA	PDE6B
Description		galactosidase alpha	phosphodiesterase 6B
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Lysosome Golgi Apparatus Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome	Cell Plasma Membrane Photoreceptor Disc Membrane
	Molecular Function	Catalytic Activity Alpha-galactosidase Activity Signaling Receptor Binding Protein Binding Hydrolase Activity Galactoside Binding Protein Homodimerization Activity Raffinose Alpha-galactosidase Activity	Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	Glycosphingolipid Metabolic Process Oligosaccharide Metabolic Process Glycoside Catabolic Process Neutrophil Degranulation Negative Regulation Of Nitric Oxide Biosynthetic Process Glycosylceramide Catabolic Process Glycosphingolipid Catabolic Process Negative Regulation Of Nitric-oxide Synthase Activity	G Protein-coupled Receptor Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Visual Perception Phototransduction, Visible Light Rhodopsin Mediated Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Regulation Of Cytosolic Calcium Ion Concentration Retina Development In Camera-type Eye
Pathways		Glycosphingolipid metabolism Neutrophil degranulation	Activation of the phototransduction cascade Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Ca2+ pathway Ca2+ pathway
Drugs		Migalastat	Caffeine Trapidil
Diseases		Fabry disease	Congenital stationary night blindness (CSNB), including: CSNB type 1 (CSNB1); CSNB type 2 (CSNB2); CSNB autosomal dominant (CSNBAD); Oguchi disease/ CSNB Oguchi type (CSNBO) Retinitis pigmentosa (RP)
GWAS
Interacting Genes		13 interacting genes: ANKRD30A CCR2 COL4A5 DUSP6 GPR17 GUCY2F HNRNPH2 MORF4L2 NAP1L3 NOSTRIN PDE6B PLP1 TERT	2 interacting genes: GLA THTPA
Entrez ID		2717	5158
HPRD ID		02357	01571
Ensembl ID		ENSG00000102393	ENSG00000133256
Uniprot IDs		P06280 Q53Y83	B4DHV7 P35913
PDB IDs		1R46 1R47 3GXN 3GXP 3GXT 3HG2 3HG3 3HG4 3HG5 3LX9 3LXA 3LXB 3LXC 3S5Y 3S5Z 3TV8 4NXS 6IBK 6IBM 6IBR 6IBT
Enriched GO Terms of Interacting Partners?
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