GLA and NOSTRIN

		GLA	NOSTRIN
Description		galactosidase alpha	nitric oxide synthase trafficking
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GO Annotations	Cellular Component	Extracellular Region Cytoplasm Lysosome Golgi Apparatus Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome	Nucleus Cytoskeleton Plasma Membrane Endocytic Vesicle Membrane
	Molecular Function	Catalytic Activity Alpha-galactosidase Activity Signaling Receptor Binding Protein Binding Hydrolase Activity Galactoside Binding Protein Homodimerization Activity Raffinose Alpha-galactosidase Activity	DNA Binding Protein Binding
	Biological Process	Glycosphingolipid Metabolic Process Oligosaccharide Metabolic Process Glycoside Catabolic Process Neutrophil Degranulation Negative Regulation Of Nitric Oxide Biosynthetic Process Glycosylceramide Catabolic Process Glycosphingolipid Catabolic Process Negative Regulation Of Nitric-oxide Synthase Activity	Endocytosis Negative Regulation Of Transcription, DNA-templated Regulation Of Nitric-oxide Synthase Activity
Pathways		Glycosphingolipid metabolism Neutrophil degranulation	NOSTRIN mediated eNOS trafficking
Drugs		Migalastat
Diseases		Fabry disease
GWAS			Granulocyte count ( 27863252) Height ( 28552196) Mitochondrial DNA levels ( 25240745) Monocyte count ( 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252)
Interacting Genes		13 interacting genes: ANKRD30A CCR2 COL4A5 DUSP6 GPR17 GUCY2F HNRNPH2 MORF4L2 NAP1L3 NOSTRIN PDE6B PLP1 TERT	5 interacting genes: APC GLA KDM1A NOS3 PRMT6
Entrez ID		2717	115677
HPRD ID		02357	06324
Ensembl ID		ENSG00000102393	ENSG00000163072
Uniprot IDs		P06280 Q53Y83	Q8IVI9
PDB IDs		1R46 1R47 3GXN 3GXP 3GXT 3HG2 3HG3 3HG4 3HG5 3LX9 3LXA 3LXB 3LXC 3S5Y 3S5Z 3TV8 4NXS 6IBK 6IBM 6IBR 6IBT	2YUN
Enriched GO Terms of Interacting Partners?
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