GH1 and PRLR

Number of citations of the paper that reports this interaction (PubMedID 9556914)
2

Data Source:
HPRD (in vitro)

		GH1	PRLR
Description		growth hormone 1	prolactin receptor
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endosome Lumen Collagen-containing Extracellular Matrix Growth Hormone Receptor Complex	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Endosome Lumen Receptor Complex
	Molecular Function	Growth Hormone Receptor Binding Prolactin Receptor Binding Hormone Activity Protein Binding Growth Factor Activity Metal Ion Binding	Cytokine Receptor Activity Prolactin Receptor Activity Protein Binding Peptide Hormone Binding Cytokine Binding Metal Ion Binding
	Biological Process	Positive Regulation Of Receptor Internalization Positive Regulation Of Activation Of Janus Kinase Activity Positive Regulation Of Glucose Transmembrane Transport Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Response To Nutrient Levels Response To Estradiol Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of MAP Kinase Activity Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Growth Positive Regulation Of JAK-STAT Cascade Animal Organ Development Positive Regulation Of Peptidyl-tyrosine Phosphorylation Growth Hormone Receptor Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Bone Maturation	Steroid Biosynthetic Process Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity JAK-STAT Cascade Embryo Implantation Lactation Response To Bacterium Regulation Of Cell Adhesion Regulation Of Epithelial Cell Differentiation Prolactin Signaling Pathway Activation Of Janus Kinase Activity Negative Regulation Of Apoptotic Process JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Mammary Gland Epithelial Cell Differentiation Prostate Gland Growth Mammary Gland Alveolus Development Positive Regulation Of Cold-induced Thermogenesis
Pathways		Prolactin receptor signaling Prolactin receptor signaling Synthesis, secretion, and deacylation of Ghrelin Growth hormone receptor signaling Growth hormone receptor signaling	Prolactin receptor signaling Prolactin receptor signaling Growth hormone receptor signaling
Drugs			Somatotropin Fluoxymesterone
Diseases		Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS			Advanced age-related macular degeneration ( 26691988) Chronotype ( 30696823) Metabolite levels ( 23823483) Paneth cell defects in Crohn's disease ( 28352666) Psychotic experience ( 31553412) Response to lurasidone in schizophrenia ( 29730043)
Interacting Genes		4 interacting genes: GHR PRLR SHC1 TREM2	19 interacting genes: CISH CREBBP CSH1 FBXW11 GH1 JAK2 MFGE8 NEK3 PPIA PRL PTPN11 SOCS2 SOCS3 TEC VAV1 VAV2 YWHAG YWHAZ ZAP70
Entrez ID		2688	5618
HPRD ID		00751	01457
Ensembl ID		ENSG00000259384	ENSG00000113494
Uniprot IDs		B1A4G6 B1A4G7 P01241	P16471
PDB IDs		1A22 1AXI 1BP3 1HGU 1HUW 1HWG 1HWH 1KF9 3HHR	1BP3 2LFG 2N7I 3D48 3MZG 3N06 3N0P 3NCB 3NCC 3NCE 3NCF 4I18
Enriched GO Terms of Interacting Partners?
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