GH1 and GHR

Number of citations of the paper that reports this interaction (PubMedID 17500058)
29

Data Source:
BioGRID (pull down, pull down, biochemical)

		GH1	GHR
Description		growth hormone 1	growth hormone receptor
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endosome Lumen Collagen-containing Extracellular Matrix Growth Hormone Receptor Complex	Extracellular Region Extracellular Space Cytosol Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Cytoplasmic Ribonucleoprotein Granule Receptor Complex Growth Hormone Receptor Complex
	Molecular Function	Growth Hormone Receptor Binding Prolactin Receptor Binding Hormone Activity Protein Binding Growth Factor Activity Metal Ion Binding	Cytokine Receptor Activity Growth Hormone Receptor Activity Protein Binding Peptide Hormone Binding Growth Factor Binding Protein Kinase Binding Cytokine Binding Identical Protein Binding Protein Homodimerization Activity Proline-rich Region Binding
	Biological Process	Positive Regulation Of Receptor Internalization Positive Regulation Of Activation Of Janus Kinase Activity Positive Regulation Of Glucose Transmembrane Transport Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Response To Nutrient Levels Response To Estradiol Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of MAP Kinase Activity Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Growth Positive Regulation Of JAK-STAT Cascade Animal Organ Development Positive Regulation Of Peptidyl-tyrosine Phosphorylation Growth Hormone Receptor Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Bone Maturation	Activation Of MAPK Activity Endocytosis JAK-STAT Cascade Cytokine-mediated Signaling Pathway Taurine Metabolic Process Cellular Response To Hormone Stimulus Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Hormone Metabolic Process Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Activation Of Janus Kinase Activity Positive Regulation Of JAK-STAT Cascade Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Growth Hormone Receptor Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway
Pathways		Prolactin receptor signaling Prolactin receptor signaling Synthesis, secretion, and deacylation of Ghrelin Growth hormone receptor signaling Growth hormone receptor signaling	Prolactin receptor signaling Growth hormone receptor signaling Growth hormone receptor signaling
Drugs			Somatotropin Pegvisomant
Diseases		Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)	Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS			Blood protein levels ( 30072576 29875488) Familial squamous cell lung carcinoma ( 29924316) Heel bone mineral density ( 30598549) Height ( 28552196 25429064 31562340) Iron status biomarkers ( 19084217) Menarche (age at onset) ( 25231870) Plasma renin activity levels ( 29650764) Response to taxane treatment (docetaxel) ( 23006423) Systemic lupus erythematosus ( 18204098)
Interacting Genes		4 interacting genes: GHR PRLR SHC1 TREM2	45 interacting genes: AP2A1 BTRC CISH CLCC1 CUL1 CUL5 DUSP7 ELOB ELOC FBXO31 GH1 GH2 GRB10 GRB2 IRS1 JAK1 JAK2 NCOA6 NEDD8 PIK3R1 PIK3R2 PLCG1 PTPN1 PTPN11 PTPN13 PTPN2 PTPN3 PTPN6 PTPN9 PTPRB PTPRH RBX1 RNF7 SGTA SHC1 SKP1 SOCS1 SOCS2 SOCS3 SRPK2 STAT3 STAT5A STAT5B STUB1 TYK2
Entrez ID		2688	2690
HPRD ID		00751	02971
Ensembl ID		ENSG00000259384	ENSG00000112964
Uniprot IDs		B1A4G6 B1A4G7 P01241	A0A087X0H5 A0A087X162 P10912
PDB IDs		1A22 1AXI 1BP3 1HGU 1HUW 1HWG 1HWH 1KF9 3HHR	1A22 1AXI 1HWG 1HWH 1KF9 2AEW 3HHR 5OEK 5OHD
Enriched GO Terms of Interacting Partners?
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