GH1 and TREM2

Number of citations of the paper that reports this interaction (PubMedID 27477018)
134

Data Source:
BioGRID (pull down)

		GH1	TREM2
Description		growth hormone 1	triggering receptor expressed on myeloid cells 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endosome Lumen Collagen-containing Extracellular Matrix Growth Hormone Receptor Complex	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Intrinsic Component Of Plasma Membrane
	Molecular Function	Growth Hormone Receptor Binding Prolactin Receptor Binding Hormone Activity Protein Binding Growth Factor Activity Metal Ion Binding	Lipopolysaccharide Binding Amyloid-beta Binding Protein Binding Phospholipid Binding High-density Lipoprotein Particle Binding Lipid Binding Low-density Lipoprotein Particle Binding Apolipoprotein Binding Apolipoprotein A-I Binding Very-low-density Lipoprotein Particle Binding Signaling Receptor Activity Peptidoglycan Binding Protein-containing Complex Binding Lipoteichoic Acid Binding Lipoprotein Particle Binding Scaffold Protein Binding Protein Tyrosine Kinase Binding
	Biological Process	Positive Regulation Of Receptor Internalization Positive Regulation Of Activation Of Janus Kinase Activity Positive Regulation Of Glucose Transmembrane Transport Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Response To Nutrient Levels Response To Estradiol Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of MAP Kinase Activity Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Growth Positive Regulation Of JAK-STAT Cascade Animal Organ Development Positive Regulation Of Peptidyl-tyrosine Phosphorylation Growth Hormone Receptor Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Bone Maturation	Microglial Cell Activation Positive Regulation Of Protein Phosphorylation Microglial Cell Activation Involved In Immune Response Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Response To Ischemia Phagocytosis, Engulfment Humoral Immune Response Regulation Of Gene Expression Negative Regulation Of Autophagy Positive Regulation Of Gene Expression Positive Regulation Of Mitochondrion Organization Osteoclast Differentiation Regulation Of TOR Signaling Positive Regulation Of TOR Signaling Detection Of Lipopolysaccharide Detection Of Peptidoglycan Regulation Of Interleukin-6 Production Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Macrophage Fusion Defense Response To Bacterium Negative Regulation Of Apoptotic Process Apoptotic Cell Clearance Innate Immune Response Regulation Of Innate Immune Response Positive Regulation Of Osteoclast Differentiation Astrocyte Activation Positive Regulation Of Protein Secretion Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Chemotaxis Regulation Of Resting Membrane Potential Positive Regulation Of Phagocytosis, Engulfment Microglial Cell Proliferation Positive Regulation Of ERK1 And ERK2 Cascade Detection Of Lipoteichoic Acid Cellular Response To Lipoteichoic Acid Cellular Response To Peptidoglycan Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Dendritic Cell Differentiation Amyloid-beta Clearance Import Into Cell Regulation Of Plasma Membrane Bounded Cell Projection Organization Complement-mediated Synapse Pruning Positive Regulation Of Amyloid-beta Clearance Positive Regulation Of Engulfment Of Apoptotic Cell Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Inward Rectifier Potassium Channel Activity Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of C-C Chemokine Receptor CCR7 Signaling Pathway Positive Regulation Of Microglial Cell Activation Negative Regulation Of Autophagic Cell Death Positive Regulation Of Microglial Cell Migration Cellular Response To Amyloid-beta Positive Regulation Of CAMKK-AMPK Signaling Cascade Positive Regulation Of CD40 Signaling Pathway Positive Regulation Of ATP Biosynthetic Process
Pathways		Prolactin receptor signaling Prolactin receptor signaling Synthesis, secretion, and deacylation of Ghrelin Growth hormone receptor signaling Growth hormone receptor signaling	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions DAP12 signaling DAP12 signaling Other semaphorin interactions
Drugs
Diseases		Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)	Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL); Nasu-Hakola disease
GWAS			Alzheimer's disease ( 23150908) Alzheimer's disease (late onset) ( 28714976) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Blood protein levels ( 30072576) C-reactive protein ( 22939635) Family history of Alzheimer's disease ( 30617256) Supraventricular ectopy ( 29618737)
Interacting Genes		4 interacting genes: GHR PRLR SHC1 TREM2	10 interacting genes: APOA1 APOA2 APOB APOE CLU GH1 NRN1L SCGB2A2 TYROBP UNC5B
Entrez ID		2688	54209
HPRD ID		00751	05473
Ensembl ID		ENSG00000259384	ENSG00000095970
Uniprot IDs		B1A4G6 B1A4G7 P01241	Q5TCX1 Q9NZC2
PDB IDs		1A22 1AXI 1BP3 1HGU 1HUW 1HWG 1HWH 1KF9 3HHR	5ELI 5UD7 5UD8 6B8O
Enriched GO Terms of Interacting Partners?
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