GGT1 and NAMPT

Number of citations of the paper that reports this interaction (PubMedID 18486613)
8

Data Source:
BioGRID (two hybrid)

		GGT1	NAMPT
Description		gamma-glutamyltransferase 1	nicotinamide phosphoribosyltransferase
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GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Membrane Extracellular Exosome	Cytosol Plasma Membrane Nuclear Speck Cell Junction Extracellular Exosome
	Molecular Function	Peptidyltransferase Activity Leukotriene-C(4) Hydrolase Protein Binding Glutathione Hydrolase Activity Hypoglycin A Gamma-glutamyl Transpeptidase Activity Leukotriene C4 Gamma-glutamyl Transferase Activity	Nicotinate-nucleotide Diphosphorylase (carboxylating) Activity Cytokine Activity Protein Binding Drug Binding Identical Protein Binding Nicotinamide Phosphoribosyltransferase Activity
	Biological Process	Regulation Of Immune System Process Translation Proteolysis Cellular Amino Acid Metabolic Process Glutamate Metabolic Process Fatty Acid Metabolic Process Leukotriene Metabolic Process Glutathione Biosynthetic Process Glutathione Catabolic Process Xenobiotic Metabolic Process Spermatogenesis Cysteine Biosynthetic Process Peptide Modification Zymogen Activation Response To Estradiol Response To Lipopolysaccharide Response To Tumor Necrosis Factor Regulation Of Inflammatory Response Leukotriene D4 Biosynthetic Process	Microglial Cell Activation Signal Transduction Cell-cell Signaling Female Pregnancy Aging Circadian Rhythm Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Negative Regulation Of Autophagy Response To Organic Cyclic Compound Regulation Of Lung Blood Pressure Circadian Regulation Of Gene Expression NAD Biosynthesis Via Nicotinamide Riboside Salvage Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Adipose Tissue Development Neuron Death Cellular Response To Ionizing Radiation Cellular Response To Oxygen-glucose Deprivation Cellular Response To Amyloid-beta Response To D-galactose Negative Regulation Of Cellular Senescence
Pathways		Glutathione synthesis and recycling Synthesis of Leukotrienes (LT) and Eoxins (EX) Aflatoxin activation and detoxification Defective GGT1 causes Glutathionuria (GLUTH) Defective GGT1 causes Glutathionuria (GLUTH) LTC4-CYSLTR mediated IL4 production	BMAL1:CLOCK,NPAS2 activates circadian gene expression Nicotinamide salvaging
Drugs		Glutathione	GMX1777 Daporinad
Diseases
GWAS		Acne (severe) ( 24927181) Blood metabolite levels ( 24816252) Blood protein levels ( 23696881) Gamma glutamyl transferase levels ( 29403010) Gamma glutamyl transpeptidase ( 21909109) Hematological and biochemical traits ( 20139978) Liver enzyme levels ( 18940312) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Protein quantitative trait loci ( 18464913) Serum metabolite levels ( 23093944) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995)	Grapefruit juice consumption ( 31046077)
Interacting Genes		3 interacting genes: CD53 KCNMA1 NAMPT	5 interacting genes: ADORA2A AKT2 FANCA GGT1 LOX
Entrez ID		2678	10135
HPRD ID		01980	09938
Ensembl ID		ENSG00000100031	ENSG00000105835
Uniprot IDs		A0A140VJJ9 P19440	A0A024R718 P43490
PDB IDs		4GDX 4GG2 4Z9O 4ZBK 4ZC6 4ZCG 5V4Q	2E5B 2E5C 2E5D 2GVG 2GVJ 3DGR 3DHD 3DHF 3DKJ 3DKL 4JNM 4JR5 4KFN 4KFO 4KFP 4L4L 4L4M 4LTS 4LV9 4LVA 4LVB 4LVD 4LVF 4LVG 4LWW 4M6P 4M6Q 4N9B 4N9C 4N9D 4N9E 4O0Z 4O10 4O12 4O13 4O14 4O15 4O16 4O17 4O18 4O19 4O1A 4O1B 4O1C 4O1D 4O28 4WQ6 5KIT 5LX3 5LX5 5NSD 5U2M 5U2N 5UPE 5UPF 5WI0 5WI1 6ATB 6AZJ 6B75 6B76 6E68
Enriched GO Terms of Interacting Partners?
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