NAMPT and GGT1

Number of citations of the paper that reports this interaction (PubMedID 18486613)
8

Data Source:
BioGRID (two hybrid)

		NAMPT	GGT1
Description		nicotinamide phosphoribosyltransferase	gamma-glutamyltransferase 1
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Nuclear Speck Cell Junction Extracellular Exosome	Extracellular Space Plasma Membrane Integral Component Of Membrane Extracellular Exosome
	Molecular Function	Nicotinate-nucleotide Diphosphorylase (carboxylating) Activity Cytokine Activity Protein Binding Drug Binding Identical Protein Binding Nicotinamide Phosphoribosyltransferase Activity	Peptidyltransferase Activity Leukotriene-C(4) Hydrolase Protein Binding Glutathione Hydrolase Activity Hypoglycin A Gamma-glutamyl Transpeptidase Activity Leukotriene C4 Gamma-glutamyl Transferase Activity
	Biological Process	Microglial Cell Activation Signal Transduction Cell-cell Signaling Female Pregnancy Aging Circadian Rhythm Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Negative Regulation Of Autophagy Response To Organic Cyclic Compound Regulation Of Lung Blood Pressure Circadian Regulation Of Gene Expression NAD Biosynthesis Via Nicotinamide Riboside Salvage Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Adipose Tissue Development Neuron Death Cellular Response To Ionizing Radiation Cellular Response To Oxygen-glucose Deprivation Cellular Response To Amyloid-beta Response To D-galactose Negative Regulation Of Cellular Senescence	Regulation Of Immune System Process Translation Proteolysis Cellular Amino Acid Metabolic Process Glutamate Metabolic Process Fatty Acid Metabolic Process Leukotriene Metabolic Process Glutathione Biosynthetic Process Glutathione Catabolic Process Xenobiotic Metabolic Process Spermatogenesis Cysteine Biosynthetic Process Peptide Modification Zymogen Activation Response To Estradiol Response To Lipopolysaccharide Response To Tumor Necrosis Factor Regulation Of Inflammatory Response Leukotriene D4 Biosynthetic Process
Pathways		BMAL1:CLOCK,NPAS2 activates circadian gene expression Nicotinamide salvaging	Glutathione synthesis and recycling Synthesis of Leukotrienes (LT) and Eoxins (EX) Aflatoxin activation and detoxification Defective GGT1 causes Glutathionuria (GLUTH) Defective GGT1 causes Glutathionuria (GLUTH) LTC4-CYSLTR mediated IL4 production
Drugs		GMX1777 Daporinad	Glutathione
Diseases
GWAS		Grapefruit juice consumption ( 31046077)	Acne (severe) ( 24927181) Blood metabolite levels ( 24816252) Blood protein levels ( 23696881) Gamma glutamyl transferase levels ( 29403010) Gamma glutamyl transpeptidase ( 21909109) Hematological and biochemical traits ( 20139978) Liver enzyme levels ( 18940312) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Protein quantitative trait loci ( 18464913) Serum metabolite levels ( 23093944) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995)
Interacting Genes		5 interacting genes: ADORA2A AKT2 FANCA GGT1 LOX	3 interacting genes: CD53 KCNMA1 NAMPT
Entrez ID		10135	2678
HPRD ID		09938	01980
Ensembl ID		ENSG00000105835	ENSG00000100031
Uniprot IDs		A0A024R718 P43490	A0A140VJJ9 P19440
PDB IDs		2E5B 2E5C 2E5D 2GVG 2GVJ 3DGR 3DHD 3DHF 3DKJ 3DKL 4JNM 4JR5 4KFN 4KFO 4KFP 4L4L 4L4M 4LTS 4LV9 4LVA 4LVB 4LVD 4LVF 4LVG 4LWW 4M6P 4M6Q 4N9B 4N9C 4N9D 4N9E 4O0Z 4O10 4O12 4O13 4O14 4O15 4O16 4O17 4O18 4O19 4O1A 4O1B 4O1C 4O1D 4O28 4WQ6 5KIT 5LX3 5LX5 5NSD 5U2M 5U2N 5UPE 5UPF 5WI0 5WI1 6ATB 6AZJ 6B75 6B76 6E68	4GDX 4GG2 4Z9O 4ZBK 4ZC6 4ZCG 5V4Q
Enriched GO Terms of Interacting Partners?
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