GCSH and SFI1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		GCSH	SFI1
Description		glycine cleavage system protein H	SFI1 centrin binding protein
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Glycine Cleavage Complex	Centrosome Centriole Cytosol
	Molecular Function	Aminomethyltransferase Activity Protein Binding	Protein Binding Phosphatase Binding
	Biological Process	Glycine Catabolic Process Protein Lipoylation Glycine Decarboxylation Via Glycine Cleavage System	G2/M Transition Of Mitotic Cell Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Phosphatase Activity Ciliary Basal Body-plasma Membrane Docking
Pathways		Glyoxylate metabolism and glycine degradation Glycine degradation	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs		Glycine 6-(Hydroxyethyldithio)-8-(Aminomethylthio)Octanoic Acid Dihydrolipoic Acid
Diseases		Nonketotic hyperglycinemia; Glycine encephalopathy (GCE)
GWAS		Glycine levels ( 31070104 30837465) Metabolite levels (small molecules and protein measures) ( 27005778) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Age-related hearing impairment ( 24939585) Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Metabolite levels ( 23823483) Type 2 diabetes ( 31118516)
Interacting Genes		4 interacting genes: ING5 NMI SFI1 ZBTB16	14 interacting genes: CCDC120 CCDC57 CETN2 CRX FAM131C GCSH GOLGA2 KRT19 LPXN MAD2L2 MDFI RADIL RBPMS SERTAD1
Entrez ID		2653	9814
HPRD ID		01998	11550
Ensembl ID		ENSG00000140905	ENSG00000198089
Uniprot IDs		P23434	A8K8P3
PDB IDs			2K2I
Enriched GO Terms of Interacting Partners?
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