KAT2A and TRRAP

Number of citations of the paper that reports this interaction (PubMedID 20946988)
302

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo, in vitro)

		KAT2A	TRRAP
Description		lysine acetyltransferase 2A	transformation/transcription domain associated protein
Image			No pdb structure
GO Annotations	Cellular Component	Histone Acetyltransferase Complex Nuclear Chromatin Extracellular Space Nucleus Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex Centrosome STAGA Complex Transcription Factor TFTC Complex Oxoglutarate Dehydrogenase Complex Mitotic Spindle	SAGA Complex PCAF Complex Swr1 Complex Nucleus Nucleoplasm Golgi Apparatus STAGA Complex Transcription Factor TFTC Complex NuA4 Histone Acetyltransferase Complex
	Molecular Function	Chromatin Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Transcription Factor Binding H3 Histone Acetyltransferase Activity Protein Phosphatase Binding Histone Deacetylase Binding Histone Acetyltransferase Activity (H4-K12 Specific) Peptide-lysine-N-acetyltransferase Activity Histone Succinyltransferase Activity	Transcription Coregulator Activity Protein Binding
	Biological Process	In Utero Embryonic Development Somitogenesis Cytokine Production Neural Tube Closure Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Heart Development Long-term Memory Cell Proliferation Response To Organic Cyclic Compound Viral Process Histone Acetylation Histone Deubiquitination Protein Deubiquitination Internal Peptidyl-lysine Acetylation Telencephalon Development Metencephalon Development Midbrain Development Positive Regulation Of Cell Projection Organization Regulation Of Protein Stability Response To Nutrient Levels Positive Regulation Of Histone Acetylation Multicellular Organism Growth Histone H3 Acetylation Histone H4-K12 Acetylation Histone H3-K14 Acetylation Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Gluconeogenesis Positive Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Centriole Replication Regulation Of Synaptic Plasticity Intracellular Distribution Of Mitochondria Regulation Of T Cell Activation Limb Development Regulation Of Cartilage Development Cellular Response To Tumor Necrosis Factor Alpha-tubulin Acetylation Histone Succinylation Regulation Of Bone Development Cellular Response To Nerve Growth Factor Stimulus Regulation Of Stem Cell Population Maintenance Positive Regulation Of Cardiac Muscle Cell Differentiation	DNA Repair Regulation Of Transcription, DNA-templated Histone Acetylation Histone Deubiquitination Protein Deubiquitination Histone H4 Acetylation Histone H2A Acetylation Beta-catenin-TCF Complex Assembly
Pathways		Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HATs acetylate histones Notch-HLH transcription pathway B-WICH complex positively regulates rRNA expression Ub-specific processing proteases RNA Polymerase I Transcription Initiation RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription	Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex HATs acetylate histones Ub-specific processing proteases
Drugs		Coenzyme A
Diseases
GWAS		Coronary artery disease ( 29212778) Inflammatory bowel disease ( 26278503) Vitiligo ( 27723757) vWF and FVIII levels ( 30586737)	Mean corpuscular volume ( 27863252)
Interacting Genes		60 interacting genes: AKT1 ATXN7 BATF2 BECN1 CCND2 CCNE1 CDK2 CDK6 CDKN2B CEBPB COMMD1 CREBBP CRX CTNNB1 CUL2 DTL EID1 EP300 FZR1 GATA2 GRM1 H1-5 H2AC20 H2BC21 H3-4 H3C14 H4-16 H4C14 HSD11B2 IRF1 IRF2 IRF7 KDELR2 LATS2 MAP2K3 MAPK14 MYB MYC NF2 NOTCH1 PBX1 PPARG PRKDC PYGO2 RASSF1 RBPJ RELA SIRT2 STK11 TACC1 TACC2 TACC3 TADA2A TCF3 TP53 TRRAP TSC1 TTYH2 UBE2I XRCC6	17 interacting genes: ACTL6A ATXN7 AURKA BRCA1 BRD8 CTNNB1 E2F1 E2F4 EP400 ESR1 KAT2A MAX MRGBP MYC PYGO2 SKP1 TCF3
Entrez ID		2648	8295
HPRD ID		03807	04310
Ensembl ID		ENSG00000108773	ENSG00000196367
Uniprot IDs		Q92830	Q9Y4A5
PDB IDs		1F68 1Z4R 3D7C 5H84 5H86 5MLJ 5TRL 5TRM 6J3P
Enriched GO Terms of Interacting Partners?
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