KAT2A and PRKDC

Number of citations of the paper that reports this interaction (PubMedID 9488450)
33

Data Source:
BioGRID (enzymatic study)

		KAT2A	PRKDC
Description		lysine acetyltransferase 2A	protein kinase, DNA-activated, catalytic subunit
Image
GO Annotations	Cellular Component	Histone Acetyltransferase Complex Nuclear Chromatin Extracellular Space Nucleus Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex Centrosome STAGA Complex Transcription Factor TFTC Complex Oxoglutarate Dehydrogenase Complex Mitotic Spindle	Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytosol DNA-dependent Protein Kinase-DNA Ligase 4 Complex Membrane Protein-containing Complex Protein-DNA Complex Nonhomologous End Joining Complex
	Molecular Function	Chromatin Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Transcription Factor Binding H3 Histone Acetyltransferase Activity Protein Phosphatase Binding Histone Deacetylase Binding Histone Acetyltransferase Activity (H4-K12 Specific) Peptide-lysine-N-acetyltransferase Activity Histone Succinyltransferase Activity	Double-stranded DNA Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity DNA-dependent Protein Kinase Activity Protein Binding ATP Binding Transcription Factor Binding Enzyme Binding Protein Domain Specific Binding
	Biological Process	In Utero Embryonic Development Somitogenesis Cytokine Production Neural Tube Closure Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Heart Development Long-term Memory Cell Proliferation Response To Organic Cyclic Compound Viral Process Histone Acetylation Histone Deubiquitination Protein Deubiquitination Internal Peptidyl-lysine Acetylation Telencephalon Development Metencephalon Development Midbrain Development Positive Regulation Of Cell Projection Organization Regulation Of Protein Stability Response To Nutrient Levels Positive Regulation Of Histone Acetylation Multicellular Organism Growth Histone H3 Acetylation Histone H4-K12 Acetylation Histone H3-K14 Acetylation Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Gluconeogenesis Positive Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Centriole Replication Regulation Of Synaptic Plasticity Intracellular Distribution Of Mitochondria Regulation Of T Cell Activation Limb Development Regulation Of Cartilage Development Cellular Response To Tumor Necrosis Factor Alpha-tubulin Acetylation Histone Succinylation Regulation Of Bone Development Cellular Response To Nerve Growth Factor Stimulus Regulation Of Stem Cell Population Maintenance Positive Regulation Of Cardiac Muscle Cell Differentiation	Telomere Maintenance Somitogenesis Negative Regulation Of Protein Phosphorylation Activation Of Innate Immune Response B Cell Lineage Commitment Pro-B Cell Differentiation T Cell Lineage Commitment Negative Regulation Of Immunoglobulin Production Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Cellular Protein Modification Process Protein Phosphorylation Cellular Response To DNA Damage Stimulus Brain Development Heart Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Gamma Radiation Response To Activity Telomere Capping Protein Ubiquitination Peptidyl-serine Phosphorylation Protein Destabilization Positive Regulation Of Type I Interferon Production Cellular Response To Insulin Stimulus T Cell Differentiation In Thymus Immunoglobulin V(D)J Recombination T Cell Receptor V(D)J Recombination Ectopic Germ Cell Programmed Cell Death Regulation Of Circadian Rhythm Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fibroblast Proliferation Rhythmic Process Spleen Development Thymus Development Positive Regulation Of Developmental Growth Regulation Of Smooth Muscle Cell Proliferation Regulation Of Epithelial Cell Proliferation Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Double-strand Break Repair Via Alternative Nonhomologous End Joining Negative Regulation Of Cellular Senescence Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of Response To Gamma Radiation
Pathways		Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HATs acetylate histones Notch-HLH transcription pathway B-WICH complex positively regulates rRNA expression Ub-specific processing proteases RNA Polymerase I Transcription Initiation RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription	Cytosolic sensors of pathogen-associated DNA IRF3-mediated induction of type I IFN Nonhomologous End-Joining (NHEJ) E3 ubiquitin ligases ubiquitinate target proteins
Drugs		Coenzyme A	Caffeine SF1126
Diseases
GWAS		Coronary artery disease ( 29212778) Inflammatory bowel disease ( 26278503) Vitiligo ( 27723757) vWF and FVIII levels ( 30586737)
Interacting Genes		60 interacting genes: AKT1 ATXN7 BATF2 BECN1 CCND2 CCNE1 CDK2 CDK6 CDKN2B CEBPB COMMD1 CREBBP CRX CTNNB1 CUL2 DTL EID1 EP300 FZR1 GATA2 GRM1 H1-5 H2AC20 H2BC21 H3-4 H3C14 H4-16 H4C14 HSD11B2 IRF1 IRF2 IRF7 KDELR2 LATS2 MAP2K3 MAPK14 MYB MYC NF2 NOTCH1 PBX1 PPARG PRKDC PYGO2 RASSF1 RBPJ RELA SIRT2 STK11 TACC1 TACC2 TACC3 TADA2A TCF3 TP53 TRRAP TSC1 TTYH2 UBE2I XRCC6	89 interacting genes: ABL1 AICDA AKT1 AKT2 AP1B1 ATM ATRIP BRCA1 C1D CASP3 CCNB1 CHEK1 CHEK2 CHUK CIB1 CLK1 CTDP1 DCAF1 DCLRE1C E4F1 EIF2S2 EIF4EBP1 EP300 ERG FH GSK3A GSK3B GZMB H1-1 H1-2 H2AX HDAC3 HMGB1 HMGB2 HNRNPA1 HNRNPC HOXC4 HSF1 HSP90AA1 IKBKB ILF2 JUN KAT2A LIG4 LYN MAPK8 MBP MKNK1 MRE11 MTNR1B NBN NCF1 NCF2 NCF4 NCOA6 NR3C1 PARP1 PCNA PDX1 PGR POU2F1 PPP6C PPP6R1 PPP6R3 PRKCD RAD17 RASSF1 RBBP8 RPA1 RPA2 SGO1 SP1 SRF SUMO2 THRA THRB TOP1 TP53 TREX1 UBE2I USF1 WRN XPA XRCC4 XRCC5 XRCC6 YWHAG YWHAQ ZBTB7A
Entrez ID		2648	5591
HPRD ID		03807	02941
Ensembl ID		ENSG00000108773	ENSG00000253729
Uniprot IDs		Q92830	P78527
PDB IDs		1F68 1Z4R 3D7C 5H84 5H86 5MLJ 5TRL 5TRM 6J3P	5LUQ 5W1R 5Y3R
Enriched GO Terms of Interacting Partners?
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