FGF21 and CDC25A

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		FGF21	CDC25A
Description		fibroblast growth factor 21	cell division cycle 25A
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Fibroblast Growth Factor Receptor Binding Protein Binding Growth Factor Activity	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Kinase Binding Chaperone Binding
	Biological Process	Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Proliferation Positive Regulation Of Triglyceride Catabolic Process Regulation Of Low-density Lipoprotein Particle Clearance Response To Activity Endoplasmic Reticulum Unfolded Protein Response Response To Nutrient Levels Cellular Response To Drug Positive Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Positive Regulation Of Glucose Import Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Glucose Stimulus Cellular Response To Glucagon Stimulus Cellular Response To Low-density Lipoprotein Particle Stimulus Endothelial Cell Apoptotic Process Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Neuron Death Response To Methionine Negative Regulation Of Endothelial Cell Apoptotic Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Cell Proliferation Response To Radiation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Deubiquitination Cellular Response To UV Peptidyl-tyrosine Dephosphorylation Positive Regulation Of Mitotic Cell Cycle Cell Division Regulation Of Cell Cycle Positive Regulation Of G2/MI Transition Of Meiotic Cell Cycle
Pathways		Cellular hexose transport Assembly of active LPL and LIPC lipase complexes	Transcription of E2F targets under negative control by DREAM complex Polo-like kinase mediated events Activation of ATR in response to replication stress Ub-specific processing proteases Cyclin E associated events during G1/S transition Cyclin A/B1/B2 associated events during G2/M transition Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Cyclin A:Cdk2-associated events at S phase entry Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972) Breakfast cereal skipping frequency ( 31190057) Breakfast skipping ( 31190057) Dietary macronutrient intake ( 23372041 23636237 29988085) Resting metabolic rate ( 28476931) Retinal vascular caliber ( 21060863) Triglycerides ( 30275531) Urinary sodium excretion ( 31409800)	Blood protein levels ( 28240269) Coronary artery disease ( 29212778) Diastolic blood pressure ( 27841878) Household income (MTAG) ( 31844048) Loneliness (multivariate analysis) ( 27629369) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (diuretics) ( 31015401) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878 27618447)
Interacting Genes		6 interacting genes: CDC25A CDH7 KLB MAPK7 NEDD4 TNS2	55 interacting genes: APP AR BTRC CAMK1D CCNA1 CCNB1 CCNE1 CCNI CDK1 CDK2 CDK5 CDKN3 CHEK1 CHEK2 CSNK1A1 CUL3 CUX1 DMD DUSP8 EEF1A1 EGFR FAM193B FBXW11 FGF21 FTH1 FZR1 HDAC11 HLA-C HRAS IL3RA LMO2 MAP3K5 MAPK14 MCM3AP MTAP NAA10 NFKBIB NFYA PEX19 PIM1 PKM POLR1D RAF1 ROCK1 SCYL1 SMAD3 SOX5 SRC UBB VAMP8 XPO1 YWHAB YWHAE YWHAQ YWHAZ
Entrez ID		26291	993
HPRD ID		09447	00305
Ensembl ID		ENSG00000105550	ENSG00000164045
Uniprot IDs		Q9NSA1	A0A024R2R6 D8KXX0 K7N7S0 P30304
PDB IDs		5VAQ	1C25
Enriched GO Terms of Interacting Partners?
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