FGF21 and MAPK7

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		FGF21	MAPK7
Description		fibroblast growth factor 21	mitogen-activated protein kinase 7
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell	Nucleus Nucleoplasm Cytoplasm Cytosol PML Body
	Molecular Function	Fibroblast Growth Factor Receptor Binding Protein Binding Growth Factor Activity	MAP Kinase Activity Protein Binding ATP Binding Mitogen-activated Protein Kinase Binding
	Biological Process	Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Proliferation Positive Regulation Of Triglyceride Catabolic Process Regulation Of Low-density Lipoprotein Particle Clearance Response To Activity Endoplasmic Reticulum Unfolded Protein Response Response To Nutrient Levels Cellular Response To Drug Positive Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Positive Regulation Of Glucose Import Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Glucose Stimulus Cellular Response To Glucagon Stimulus Cellular Response To Low-density Lipoprotein Particle Stimulus Endothelial Cell Apoptotic Process Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Neuron Death Response To Methionine Negative Regulation Of Endothelial Cell Apoptotic Process	MAPK Cascade Cell Cycle Signal Transduction Axon Guidance Regulation Of Gene Expression Peptidyl-serine Phosphorylation CAMP-mediated Signaling Negative Regulation Of Heterotypic Cell-cell Adhesion Intracellular Signal Transduction Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Inflammatory Response Positive Regulation Of Protein Metabolic Process Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Negative Regulation Of Response To Cytokine Stimulus Cellular Response To Hydrogen Peroxide Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Laminar Fluid Shear Stress Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Cellular hexose transport Assembly of active LPL and LIPC lipase complexes	ERK/MAPK targets ERK/MAPK targets Signalling to ERK5 Signalling to ERK5 ERKs are inactivated Senescence-Associated Secretory Phenotype (SASP) Gastrin-CREB signalling pathway via PKC and MAPK RET signaling
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972) Breakfast cereal skipping frequency ( 31190057) Breakfast skipping ( 31190057) Dietary macronutrient intake ( 23372041 23636237 29988085) Resting metabolic rate ( 28476931) Retinal vascular caliber ( 21060863) Triglycerides ( 30275531) Urinary sodium excretion ( 31409800)	Alzheimer's disease ( 30636644)
Interacting Genes		6 interacting genes: CDC25A CDH7 KLB MAPK7 NEDD4 TNS2	28 interacting genes: ACTN4 APP EGLN3 ELK4 ETS1 FGF21 FOS GJA1 GOLGB1 GPSM3 MACIR MAP2K5 MEF2A MEF2C MEF2D MYC NFE2L2 NR1I2 PRKCZ PTPRR RAF1 RXRA SGK1 SH2D2A UBE2C YWHAB YWHAE ZBED6CL
Entrez ID		26291	5598
HPRD ID		09447	03952
Ensembl ID		ENSG00000105550	ENSG00000166484
Uniprot IDs		Q9NSA1	A0A024QZ20 Q13164
PDB IDs		5VAQ	2Q8Y 4B99 4IC7 4IC8 4ZSG 4ZSJ 4ZSL 5BYY 5BYZ 5O7I 6HKM 6HKN
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?