WHRN and LRRC4C

Number of citations of the paper that reports this interaction (PubMedID 15590698)
79

Data Source:
HPRD (in vitro, two hybrid)

		WHRN	LRRC4C
Description		whirlin	leucine rich repeat containing 4C
Image
GO Annotations	Cellular Component	Photoreceptor Inner Segment Stereocilia Ankle Link Stereocilia Ankle Link Complex Cytoplasm Actin Filament Plasma Membrane Cell Junction Growth Cone Photoreceptor Connecting Cilium Stereocilium Stereocilium Tip Ciliary Basal Body Neuronal Cell Body Synapse Periciliary Membrane Compartment USH2 Complex	Extracellular Space Membrane Integral Component Of Membrane Cell Junction Schaffer Collateral - CA1 Synapse Glutamatergic Synapse Integral Component Of Postsynaptic Density Membrane
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding Cell Adhesion Molecule Binding Cell-cell Adhesion Mediator Activity
	Biological Process	Retina Homeostasis Sensory Perception Of Sound Positive Regulation Of Gene Expression Cerebellar Purkinje Cell Layer Formation Establishment Of Protein Localization Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Sensory Perception Of Light Stimulus Auditory Receptor Cell Stereocilium Organization Inner Ear Receptor Cell Development Inner Ear Receptor Cell Stereocilium Organization Paranodal Junction Maintenance	Regulation Of Axonogenesis Modulation Of Chemical Synaptic Transmission Synaptic Membrane Adhesion
Pathways
Drugs
Diseases		Usher syndrome (US) Deafness, autosomal recessive
GWAS			Blood protein levels ( 30072576) Cerebellum cortex volume ( 31530798) Cerebrospinal fluid beta-site APP cleaving enzyme levels ( 29751835) Cerebrospinal fluid p-tau levels ( 29274321) Diastolic blood pressure response to thiazide and thiazide-like diuretics in hypertension ( 31754133) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) General risk tolerance (MTAG) ( 30643258) Iris color (L* coordinate) ( 30895295) Mosquito bite size ( 28199695) Myopia ( 27182965) Osteoporosis-related phenotypes ( 20548944) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking status (ever vs never smokers) ( 30643258) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Survival in colorectal cancer ( 26586795) Temperament (bipolar disorder) ( 22365631)
Interacting Genes		6 interacting genes: CASK LRP4 LRRC4C MYO15A MYO7A RPS6KA1	3 interacting genes: CREB3L4 NTNG1 WHRN
Entrez ID		25861	57689
HPRD ID		09718	12303
Ensembl ID		ENSG00000095397	ENSG00000148948
Uniprot IDs		B9EGE6 Q9P202	Q4JIV9 Q4JIW0 Q9HCJ2
PDB IDs		1UEZ 1UF1 1UFX	3ZYJ
Enriched GO Terms of Interacting Partners?
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