ALOX12 and KRT5

Number of citations of the paper that reports this interaction (PubMedID 10727209)
12

Data Source:
BioGRID (two hybrid, affinity chromatography technology)
HPRD (in vivo)

		ALOX12	KRT5
Description		arachidonate 12-lipoxygenase, 12S type	keratin 5
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Sarcolemma Extracellular Exosome	Nucleus Cytoplasm Cytosol Intermediate Filament Plasma Membrane Membrane Keratin Filament Extracellular Exosome
	Molecular Function	Arachidonate 12-lipoxygenase Activity Iron Ion Binding Protein Binding Linoleate 13S-lipoxygenase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Hepoxilin-epoxide Hydrolase Activity Arachidonate 15-lipoxygenase Activity	Structural Constituent Of Cytoskeleton Protein Binding Scaffold Protein Binding
	Biological Process	Lipid Metabolic Process Aging Positive Regulation Of Gene Expression Negative Regulation Of Muscle Cell Apoptotic Process Arachidonic Acid Metabolic Process Lipoxygenase Pathway Fatty Acid Oxidation Unsaturated Fatty Acid Metabolic Process Lipid Oxidation Superoxide Anion Generation Long-chain Fatty Acid Biosynthetic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Linoleic Acid Metabolic Process Positive Regulation Of Smooth Muscle Cell Proliferation Hepoxilin Metabolic Process Hepoxilin Biosynthetic Process Positive Regulation Of Mitochondrial Depolarization Establishment Of Skin Barrier Cellular Response To Lipid Negative Regulation Of Platelet Aggregation Positive Regulation Of Blood Vessel Diameter Leukotriene A4 Metabolic Process Positive Regulation Of Endothelial Tube Morphogenesis Lipoxin Biosynthetic Process Lipoxin A4 Biosynthetic Process Lipoxin B4 Biosynthetic Process	Cytoskeleton Organization Epidermis Development Keratinization Hemidesmosome Assembly Cornification
Pathways		Synthesis of Hepoxilins (HX) and Trioxilins (TrX) Synthesis of Lipoxins (LX) Synthesis of 12-eicosatetraenoic acid derivatives Biosynthesis of DHA-derived SPMs Biosynthesis of DPAn-6 SPMs Biosynthesis of DPAn-3-derived maresins	Type I hemidesmosome assembly Keratinization Formation of the cornified envelope
Drugs			Zinc
Diseases			Dowling-Degos disease Epidermolysis bullosa simplex, including: Epidermolysis bullosa simplex, Dowling-Meara type (EBS-DM); Epidermolysis bullosa simplex, Koebner type (EBS-K); Epidermolysis bullosa simplex, Weber-Cockayne type (EBS-WC); Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP); Epidermolysis bullosa simplex with migratory circinate erythema; Epidermolysis bullosa simplex, recessive; Epidermolysis bullosa, lethal acantholytic
GWAS		Blood metabolite levels ( 24816252)	Basal cell carcinoma ( 31174203 24403052 25855136 27539887) Keratinocyte cancer (MTAG) ( 31174203) Non-melanoma skin cancer ( 29739929) Squamous cell carcinoma ( 31174203)
Interacting Genes		7 interacting genes: ITGB4 KAT5 KRT5 KRT85 LMNA PLA2G2A TRIB1	17 interacting genes: ALOX12 ALOX12B APC DSP DST EVPL KIFC3 KRT1 KRT14 KRT15 KRT18 KRT31 KRT38 KRT40 PKP2 TCHP UBE3A
Entrez ID		239	3852
HPRD ID		01066	01010
Ensembl ID		ENSG00000108839	ENSG00000186081
Uniprot IDs		P18054	P13647
PDB IDs		2ABU 3D3L	3TNU
Enriched GO Terms of Interacting Partners?
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