KLF6 and KLF4

Number of citations of the paper that reports this interaction (PubMedID 10802067)
17

Data Source:
HPRD (in vivo)

		KLF6	KLF4
Description		Kruppel like factor 6	Kruppel like factor 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Fibrillar Center Nucleus Nucleoplasm Nucleolus Cytosol Intracellular Membrane-bounded Organelle	Nuclear Chromatin Nucleus Nucleoplasm Nuclear Euchromatin Cytoplasm Nuclear Transcription Factor Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Proximal Promoter Sequence-specific DNA Binding RNA Polymerase II Sequence-specific DNA-binding Transcription Factor Recruiting Activity RNA Polymerase II Transcription Factor Binding Transcription Cofactor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Beta-catenin Binding Zinc Ion Binding Phosphatidylinositol 3-kinase Regulator Activity Histone Deacetylase Binding Transcription Regulatory Region DNA Binding Promoter-specific Chromatin Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II B Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Mesodermal Cell Fate Determination Negative Regulation Of Cell Proliferation Epidermal Cell Differentiation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Muscle Hyperplasia Negative Regulation Of Angiogenesis Stem Cell Population Maintenance Post-embryonic Camera-type Eye Development Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Heterotypic Cell-cell Adhesion Somatic Stem Cell Population Maintenance Post-embryonic Hemopoiesis Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Phosphatidylinositol 3-kinase Activity Negative Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Fat Cell Differentiation Regulation Of Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Hemoglobin Biosynthetic Process Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Axon Regeneration Epidermis Morphogenesis Negative Regulation Of Inflammatory Response Positive Regulation Of Protein Metabolic Process Negative Regulation Of Protein Kinase B Signaling Positive Regulation Of Telomerase Activity Canonical Wnt Signaling Pathway Negative Regulation Of Response To Cytokine Stimulus Pri-miRNA Transcription By RNA Polymerase II Cellular Response To Hydrogen Peroxide Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Retinoic Acid Cellular Response To Growth Factor Stimulus Cellular Response To Cycloheximide Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Cellular Response To Peptide Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Core Promoter Binding Negative Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Pathways			Transcriptional regulation of white adipocyte differentiation Synthesis, secretion, and deacylation of Ghrelin Transcriptional regulation of pluripotent stem cells FOXO-mediated transcription of cell cycle genes
Drugs
Diseases
GWAS		Asthma (bronchodilator response) ( 23508266) Coronary artery calcification ( 23870195) Diastolic blood pressure ( 27841878) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Heel bone mineral density ( 30598549 28869591) Multiple sclerosis ( 31604244) Plasma anti-thyroglobulin levels ( 29678681)	Breast cancer ( 21263130) Colorectal or endometrial cancer ( 26621817) Cotinine glucuronidation ( 25293881) Cutaneous malignant melanoma ( 26237428) Glycated hemoglobin levels ( 28898252) Heel bone mineral density ( 30598549 28869591) Prostate cancer ( 23023329) Psoriasis ( 25574825 23143594) Psoriasis vulgaris ( 26626624) Takayasu arteritis ( 25604533) Tenofovir clearance in HIV infection ( 26148204)
Interacting Genes		16 interacting genes: APOM APP CELSR2 EHMT2 FBL GTF3C1 HDAC3 KLF4 LCOR NOP56 NUFIP1 PNO1 POLA2 SP1 TAF9 TP53	13 interacting genes: APP CREBBP ELK1 EP300 FBXO7 HDAC1 HDAC5 KAT5 KLF6 SETD7 SP1 TP53 VHL
Entrez ID		1316	9314
HPRD ID		03632	03769
Ensembl ID		ENSG00000067082	ENSG00000136826
Uniprot IDs		D3GC14 Q99612	O43474
PDB IDs
Enriched GO Terms of Interacting Partners?
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