MGA and E2F4

Number of citations of the paper that reports this interaction (PubMedID 12748276)
45

Data Source:
BioGRID (two hybrid)

		MGA	E2F4
Description		MAX dimerization protein MGA	E2F transcription factor 4
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm MLL1 Complex	Nuclear Chromatin Cell Nucleus Nucleoplasm Cytoplasm RNA Polymerase II Transcription Factor Complex
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Protein Dimerization Activity	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Bacterial-type RNA Polymerase Transcriptional Activator Activity, Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Domain Specific Binding Sequence-specific DNA Binding Protein Dimerization Activity Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Fate Specification Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of G0 To G1 Transition	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Epithelial Cell Development Cell Volume Homeostasis DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Blood Circulation Animal Organ Morphogenesis Regulation Of Cell Proliferation Motile Cilium Assembly Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Centriole Assembly Multi-ciliated Epithelial Cell Differentiation
Pathways		Transcriptional Regulation by E2F6	Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Cyclin E associated events during G1/S transition G1/S-Specific Transcription G1/S-Specific Transcription Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry
Drugs
Diseases
GWAS		Feeling nervous ( 29500382) Lung function (FEV1/FVC) ( 28166213 30804560) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		8 interacting genes: CBX3 E2F1 E2F3 E2F4 H3-4 LSM8 MAX SMAD1	29 interacting genes: AP3S2 ARID3A ATAD2 BRCA1 CHMP2A CHUK FHL2 HCFC1 ID3 IKBKB LRRK2 MFHAS1 MGA NDN NOLC1 PCM1 POLR1D RB1 RBL1 RBL2 RNF144A RYBP SMAD2 SMAD3 SPIB TFDP1 TFDP2 TRRAP XPO1
Entrez ID		23269	1874
HPRD ID		19055	02806
Ensembl ID		ENSG00000174197	ENSG00000205250
Uniprot IDs		Q8IWI9	Q16254
PDB IDs			1CF7 5TUU
Enriched GO Terms of Interacting Partners?
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