RHOBTB2 and CUL5

Number of citations of the paper that reports this interaction (PubMedID 18835386)
30

Data Source:
BioGRID (two hybrid)

		RHOBTB2	CUL5
Description		Rho related BTB domain containing 2	cullin 5
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cell Cortex Cytoplasmic Vesicle Cell Division Site Intracellular Membrane-bounded Organelle	Cytosol SCF Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Cul5-RING Ubiquitin Ligase Complex Site Of DNA Damage
	Molecular Function	GTPase Activity Protein Binding GTP Binding Protein Kinase Binding	Ubiquitin-protein Transferase Activity Calcium Channel Activity Protein Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity
	Biological Process	Cytokinesis Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Rho Protein Signal Transduction Regulation Of Cell Shape Regulation Of Cell Migration Establishment Or Maintenance Of Actin Cytoskeleton Polarity Regulation Of Actin Cytoskeleton Organization Actin Filament Bundle Assembly Regulation Of Small GTPase Mediated Signal Transduction	G1/S Transition Of Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Viral Process Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process ERBB2 Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Calcium Ion Transmembrane Transport Intrinsic Apoptotic Signaling Pathway
Pathways		Rho GTPase cycle	Vif-mediated degradation of APOBEC3G Downregulation of ERBB2 signaling Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Alzheimer's disease progression score ( 29860282) Height ( 28552196) Plasma trimethylamine N-oxide levels ( 28439531) Renal cell carcinoma ( 28598434) Survival in breast cancer (estrogen-receptor positive) ( 29423119)
Interacting Genes		12 interacting genes: BAG4 CHEK2 CUL5 ERBB2 FGFR2 HSP90AA1 HSP90AB1 PALB2 PPM1D PTPN1 RHOBTB3 STK11	34 interacting genes: ANAPC11 CBFB CCNDBP1 COMMD1 COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A COPS8 DCUN1D1 DDX10 DEPTOR ELOA ERCC6 GHR GOLGA2 GPS1 PRKACA PTPN5 RBX1 RHOBTB1 RHOBTB2 RHOU RNF7 SMAD2 SMURF1 SOX30 TGFBR1 TRAF6 UBC UBE2F VHL
Entrez ID		23221	8065
HPRD ID		06300	03444
Ensembl ID		ENSG00000008853	ENSG00000166266
Uniprot IDs		Q9BYZ6	Q93034
PDB IDs			3DPL 3DQV 4JGH 4N9F
Enriched GO Terms of Interacting Partners?
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