TRIM35 and USP49

Number of citations of the paper that reports this interaction (PubMedID 23105109)
16

Data Source:
BioGRID (two hybrid)

		TRIM35	USP49
Description		tripartite motif containing 35	ubiquitin specific peptidase 49
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Nucleoplasm
	Molecular Function	Molecular_function Zinc Ion Binding	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding Thiol-dependent Ubiquitinyl Hydrolase Activity Histone Binding
	Biological Process	Apoptotic Process Positive Regulation Of Apoptotic Process Innate Immune Response Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Viral Release From Host Cell	MRNA Splicing, Via Spliceosome Ubiquitin-dependent Protein Catabolic Process Protein Deubiquitination Histone H2B Conserved C-terminal Lysine Deubiquitination
Pathways		Interferon gamma signaling	Ub-specific processing proteases
Drugs
Diseases
GWAS		Chronotype ( 30696823) Crohn's disease ( 26192919) Inflammatory bowel disease ( 26192919) Lung cancer ( 28604730)	Cutaneous psoriasis ( 26626624) Mean corpuscular hemoglobin ( 20139978) Mean corpuscular volume ( 23263863 20139978 27863252) Red blood cell count ( 20139978 27863252) Skin aging (microtopography measurement) ( 28502801) Sleep duration (short sleep) ( 30846698)
Interacting Genes		14 interacting genes: PAN2 PKM TRIM11 TRIM5 TSG101 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2K UBE2U UBE2W USP2 USP49	9 interacting genes: FKBP5 H2BC21 MED17 MED18 MED8 RBCK1 STING1 TP53 TRIM35
Entrez ID		23087	25862
HPRD ID		15553	10075
Ensembl ID		ENSG00000104228	ENSG00000164663
Uniprot IDs		E5RGB3 Q9UPQ4	Q70CQ1
PDB IDs
Enriched GO Terms of Interacting Partners?
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