SHANK2 and DNAJC19

		SHANK2	DNAJC19
Description		SH3 and multiple ankyrin repeat domains 2	DnaJ heat shock protein family (Hsp40) member C19
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Cellular_component Cytosol Neurofilament Plasma Membrane Ionotropic Glutamate Receptor Complex Postsynaptic Density Apical Plasma Membrane Cell Junction Dendrite Growth Cone Brush Border Membrane Neuron Projection Neuronal Cell Body Dendritic Spine Neuron Spine Postsynaptic Membrane Ciliary Membrane	PAM Complex, Tim23 Associated Import Motor Mitochondrion Mitochondrial Inner Membrane Integral Component Of Membrane Protein-containing Complex
	Molecular Function	Protein Binding SH3 Domain Binding Receptor Signaling Complex Scaffold Activity GKAP/Homer Scaffold Activity Ionotropic Glutamate Receptor Binding	ATPase Activator Activity Protein Binding
	Biological Process	Synapse Assembly Behavior Learning Adult Behavior Social Behavior Brain Morphogenesis Synaptic Growth At Neuromuscular Junction Positive Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Potentiation Long-term Synaptic Depression Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Development Vocalization Behavior Postsynaptic Density Assembly Regulation Of AMPA Receptor Activity Positive Regulation Of Excitatory Postsynaptic Potential	Protein Folding Protein Targeting To Mitochondrion Visual Perception Protein Import Into Mitochondrial Matrix Positive Regulation Of ATPase Activity Genitalia Development
Pathways		Neurexins and neuroligins Neurexins and neuroligins	Mitochondrial protein import
Drugs
Diseases			3-Methylglutaconic aciduria (MGCA)
GWAS		Bipolar disorder ( 31043756) Hip circumference ( 28552196) Late-onset Alzheimer's disease ( 27770636) Obesity-related traits ( 23251661) Response to fenofibrate (adiponectin levels) ( 23149075) Urate levels in obese individuals ( 25811787)	Schizophrenia ( 28991256 25056061 29483656 30285260)
Interacting Genes		16 interacting genes: ADGRB2 ADGRL1 ADGRL2 ARHGEF7 BAIAP2 CTTN DLG4 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DNAJC19 DNM2 SHARPIN SLC9A3 SSTR2	10 interacting genes: APP CETN3 CLIC1 F11 HSPA9 LRRFIP2 MCPH1 PAM16 PHTF1 SHANK2
Entrez ID		22941	131118
HPRD ID		04479	12349
Ensembl ID		ENSG00000162105	ENSG00000205981
Uniprot IDs		A0A590UJ45 A6NHU9 C0SPH0 Q9UPX8	A0A0S2Z5X1 Q96DA6
PDB IDs
Enriched GO Terms of Interacting Partners?
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