MAPRE3 and AURKB

Number of citations of the paper that reports this interaction (PubMedID 19696028)
25

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		MAPRE3	AURKB
Description		microtubule associated protein RP/EB family member 3	aurora kinase B
Image
GO Annotations	Cellular Component	Cytoplasm Microtubule Organizing Center Microtubule Midbody Microtubule Plus-end Spindle Midzone Mitotic Spindle Astral Microtubule End	Kinetochore Condensed Chromosome, Centromeric Region Condensed Nuclear Chromosome, Centromeric Region Nucleus Nucleoplasm Spindle Cytosol Spindle Microtubule Chromocenter Midbody Spindle Pole Centrosome Chromosome Passenger Complex Spindle Midzone Mitotic Spindle Midzone
	Molecular Function	Protein Binding Microtubule Binding Protein C-terminus Binding Protein Kinase Binding Identical Protein Binding Microtubule Plus-end Binding	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Kinase Binding Histone Serine Kinase Activity Metal Ion Binding
	Biological Process	Protein Localization Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Microtubule Polymerization Protein Localization To Microtubule Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Transcription, DNA-templated Spindle Assembly Cell Division Positive Regulation Of Microtubule Plus-end Binding Protein Localization To Microtubule Plus-end	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of B Cell Apoptotic Process Protein Phosphorylation Ubiquitin-dependent Protein Catabolic Process Spindle Organization Mitotic Spindle Organization Mitotic Spindle Assembly Checkpoint Aging Cell Proliferation Attachment Of Spindle Microtubules To Kinetochore Abscission Histone Modification Anaphase-promoting Complex-dependent Catabolic Process Negative Regulation Of Protein Binding Positive Regulation Of Telomere Maintenance Via Telomerase Regulation Of Cytokinesis Negative Regulation Of Cytokinesis Positive Regulation Of Cytokinesis Protein Localization To Kinetochore Cellular Response To UV Cleavage Furrow Formation Histone H3-S28 Phosphorylation Mitotic Cytokinesis Checkpoint Protein Autophosphorylation Mitotic Spindle Midzone Assembly Positive Regulation Of Telomerase Activity Regulation Of Chromosome Segregation Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Telomere Capping Positive Regulation Of Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA replication proteins RHO GTPases Activate Formins Regulation of TP53 Activity through Phosphorylation Mitotic Prometaphase Regulation of MECP2 expression and activity EML4 and NUDC in mitotic spindle formation
Drugs			HESPERIDIN AT9283 N~6~-cyclohexyl-N~2~-(4-morpholin-4-ylphenyl)-9H-purine-2,6-diamine
Diseases
GWAS		Estimated glomerular filtration rate in non-diabetics ( 31451708) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		22 interacting genes: APC2 AURKA AURKB CLASP1 DCTN2 DOK4 EIF4E2 FXR2 GTSE1 JUN KIF19 LMO2 MAPRE1 MAPRE2 PSMA1 PSMB1 RAB1A SDCBP SIAH1 SLAIN1 TROAP TXN2	53 interacting genes: AJUBA ANKZF1 APP BCL2L11 BIRC5 CBX3 CDCA8 CENPA CIB1 CYLD DCUN1D1 DES EVI5 FBXL2 FLOT1 GFAP H3-4 H3C1 H3C14 HASPIN INCENP KIF20A KLHL13 KLHL21 KLHL9 LATS1 LATS2 LNX1 LRRK2 MAPRE1 MAPRE2 MAPRE3 MFHAS1 NCAPH NDC80 NINL NSUN2 NUF2 PKM PSMA3 PTPA RACGAP1 RACK1 RAD52 RASA1 RASSF1 SEPTIN1 SKA1 SKA3 TACC1 TBL3 TGFBR1 UBE2I
Entrez ID		22924	9212
HPRD ID		16156	05397
Ensembl ID		ENSG00000084764	ENSG00000178999
Uniprot IDs		Q9UPY8	Q96GD4
PDB IDs		1WYO 3CO1 3JAK 3JAL 3JAR 3TQ7	4AF3
Enriched GO Terms of Interacting Partners?
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