PUF60 and ERG

Number of citations of the paper that reports this interaction (PubMedID 24591637)
44

Data Source:
BioGRID (affinity chromatography technology, pull down)

		PUF60	ERG
Description		poly(U) binding splicing factor 60	ETS transcription factor ERG
Image
GO Annotations	Cellular Component	Nucleoplasm Cell Junction	Nuclear Chromatin Nucleus Cytoplasm Ribonucleoprotein Complex
	Molecular Function	DNA Binding RNA Binding Protein Binding Identical Protein Binding Cadherin Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome Apoptotic Process	Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Signal Transduction Multicellular Organism Development Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II
Pathways		mRNA Splicing - Major Pathway
Drugs
Diseases			Ewing's sarcoma Prostate cancer
GWAS			Abdominal aortic aneurysm ( 27899403) Amyotrophic lateral sclerosis (sporadic) ( 24529757) B-cell acute lymphoblastic leukaemia ( 31767839) B-cell acute lymphoblastic leukaemia (high-hyperdiploidy) ( 31767839) Diastolic blood pressure ( 27841878 30578418) General cognitive ability ( 25383866) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549 28869591) Iron status biomarkers (iron levels) ( 28334935) Keratinocyte cancer (MTAG) ( 31174203) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Metabolite levels (HVA) ( 23319000) Monocyte percentage of white cells ( 27863252) Multiple sclerosis ( 31604244 27386562) Neonatal lupus ( 20662065) Non-response to antidepressants and depression ( 27622933) Platelet count ( 27863252) Plateletcrit ( 27863252) Pulse pressure ( 27841878 30578418) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097) Sum eosinophil basophil counts ( 27863252) White blood cell count (basophil) ( 29403010) White blood cell types ( 21738478)
Interacting Genes		34 interacting genes: ARL8A BORCS5 CACNA1A CCNC CD101 CHD3 CPEB2 ERG FBXO7 FHL2 FUBP1 H1-2 ID3 IQCN KHDC4 LARP7 MED28 PCBP1 PPP1R16A PTBP2 QRICH1 RAD23B RAP1GDS1 SAP30BP SDCBP SIAH1 SNRPF SRSF11 U2AF2 UBE2I UPF2 VIM YWHAG ZG16	73 interacting genes: ACTB ADAR APP CDC5L CLTC DDX21 DDX23 DKC1 DNAJA1 DNAJA2 DNAJA4 EEF1A2 ELAVL1 ETS2 ETV1 FBL FLI1 HERC2 HNRNPA1 HNRNPA2B1 HNRNPAB HNRNPC HNRNPD HNRNPDL HNRNPF HNRNPH1 HNRNPH3 HNRNPU HNRNPUL1 HNRNPUL2 HSPD1 HUWE1 ILF2 ILF3 JUN LANCL1 MATR3 NCL NOLC1 NONO NPM1 NUMA1 PARP1 PCBP1 POLR2A PRKDC PRPF40A PRPF8 PUF60 RCC2 RING1 RNF2 RPLP0 SETDB1 SF3B1 SF3B2 SF3B3 SFPQ SNRNP200 SPI1 SPOP STUB1 SYN1 TOP1 TOP2B TRIM25 TRIM33 TRIP12 UBR4 UBR5 UHRF1 USP9X XRN2
Entrez ID		22827	2078
HPRD ID		18051	01298
Ensembl ID		ENSG00000179950	ENSG00000157554
Uniprot IDs		Q9UHX1	A0A0C4DG41 B4DN83 B4DVX5 B5MDW0 P11308
PDB IDs		2DNY 2KXF 2KXH 2QFJ 3DXB 3UE2 3US5 3UWT 5KVY 5KW1 5KW6 5KWQ	1SXE 4IRG 4IRH 4IRI 5YBC 5YBD
Enriched GO Terms of Interacting Partners?
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