PROC and THBD

Number of citations of the paper that reports this interaction (PubMedID 11106601)
9

Data Source:
HPRD (in vitro)

		PROC	THBD
Description		protein C, inactivator of coagulation factors Va and VIIIa	thrombomodulin
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Golgi Lumen	Extracellular Space Vacuolar Membrane Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Apicolateral Plasma Membrane
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding	Transmembrane Signaling Receptor Activity Calcium Ion Binding Protein Binding Signaling Receptor Activity
	Biological Process	Proteolysis ER To Golgi Vesicle-mediated Transport Blood Coagulation Negative Regulation Of Blood Coagulation Negative Regulation Of Apoptotic Process Post-translational Protein Modification Cellular Protein Metabolic Process Negative Regulation Of Inflammatory Response Negative Regulation Of Coagulation Positive Regulation Of Establishment Of Endothelial Barrier	Female Pregnancy Blood Coagulation Response To X-ray Negative Regulation Of Platelet Activation Negative Regulation Of Blood Coagulation Response To Lipopolysaccharide Leukocyte Migration Response To CAMP Negative Regulation Of Fibrinolysis
Pathways		Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Cell surface interactions at the vascular wall Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Common Pathway of Fibrin Clot Formation Cell surface interactions at the vascular wall
Drugs		Menadione Sodium Tetradecyl Sulfate Cupric Chloride Protein S human	Drotrecogin alfa Ibuprofen Dexibuprofen
Diseases		Inherited thrombophilia	Inherited thrombophilia
GWAS		Blood protein levels ( 30072576) Protein C levels ( 28082259 25376901 20802025)	Blood protein levels in cardiovascular risk ( 28369058) PR interval in Tripanosoma cruzi seropositivity ( 24324551) Venous thromboembolism ( 26888256)
Interacting Genes		14 interacting genes: CP CSNK2B F2 F5 F8 GGCX NGLY1 PF4 PROCR PROS1 SERPINA5 SERPINB6 THBD TK1	6 interacting genes: F2 LMNA PF4 PROC PSENEN SERPINA5
Entrez ID		5624	7056
HPRD ID		01466	01764
Ensembl ID		ENSG00000115718	ENSG00000178726
Uniprot IDs		P04070	P07204
PDB IDs		1AUT 1LQV 1PCU 2PCT 3F6U 3JTC 4DT7	1ADX 1DQB 1DX5 1EGT 1FGD 1FGE 1HLT 1TMR 1ZAQ 2ADX 3GIS 5TO3
Enriched GO Terms of Interacting Partners?
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