ABCD1 and ATP6AP1

		ABCD1	ATP6AP1
Description		ATP binding cassette subfamily D member 1	ATPase H+ transporting accessory protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosomal Membrane Peroxisome Peroxisomal Membrane Integral Component Of Peroxisomal Membrane Endoplasmic Reticulum Membrane Cytosol Membrane Mitochondrial Membrane Perinuclear Region Of Cytoplasm	Cell Endoplasmic Reticulum Membrane Endosome Membrane Integral Component Of Membrane Proton-transporting Two-sector ATPase Complex Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Proton-transporting V-type ATPase, V1 Domain Plasma Membrane Proton-transporting V-type ATPase Complex Extracellular Exosome
	Molecular Function	Long-chain Fatty Acid Transporter Activity Protein Binding ATP Binding Fatty-acyl-CoA Transmembrane Transporter Activity ATPase Activity Enzyme Binding ATPase Activity, Coupled To Transmembrane Movement Of Substances Identical Protein Binding Protein Homodimerization Activity ADP Binding	Protein Binding ATP Binding Rab GTPase Binding Proton-transporting ATP Synthase Activity, Rotational Mechanism Proton-transporting ATPase Activity, Rotational Mechanism
	Biological Process	Regulation Of Oxidative Phosphorylation Fatty Acid Beta-oxidation Peroxisome Organization Peroxisomal Long-chain Fatty Acid Import Fatty-acyl-CoA Transport Peroxisomal Membrane Transport Fatty Acid Elongation Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Fatty Acid Beta-oxidation Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Alpha-linolenic Acid Metabolic Process Very Long-chain Fatty-acyl-CoA Catabolic Process Long-chain Fatty Acid Catabolic Process Very Long-chain Fatty Acid Catabolic Process Myelin Maintenance Linoleic Acid Metabolic Process Regulation Of Mitochondrial Depolarization Transmembrane Transport Fatty Acid Homeostasis Sterol Homeostasis Negative Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Cellular Response To Oxidative Stress Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Neuron Projection Maintenance Positive Regulation Of Unsaturated Fatty Acid Biosynthetic Process	Cellular Iron Ion Homeostasis Insulin Receptor Signaling Pathway Regulation Of Cellular PH Transferrin Transport Ion Transmembrane Transport Cellular Response To Increased Oxygen Levels Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Bone Resorption PH Reduction Positive Regulation Of Exocytosis Establishment Of Organelle Localization Positive Regulation Of ERK1 And ERK2 Cascade Proton Transmembrane Transport Positive Regulation Of Osteoclast Development
Pathways		ABC transporters in lipid homeostasis Linoleic acid (LA) metabolism alpha-linolenic acid (ALA) metabolism Beta-oxidation of very long chain fatty acids Defective ABCD1 causes adrenoleukodystrophy (ALD) Class I peroxisomal membrane protein import	Insulin receptor recycling Transferrin endocytosis and recycling Ion channel transport
Drugs
Diseases		Adrenoleukodystrophy (ALD), including: Schilder-Addison Complex; Childhood cerebral adrenoleukodystrophy (CCER); adrenomyeloneuropathy (AMN)
GWAS
Interacting Genes		6 interacting genes: ABCD2 ABCD3 ATP6AP1 PEX19 RPSA SLC27A2	11 interacting genes: ABCD1 ANG CETN2 CTAG1B ERBB2 HBA1 LARP1 NR1I2 NT5E RHOU SYVN1
Entrez ID		215	537
HPRD ID		02300	02184
Ensembl ID		ENSG00000101986	ENSG00000071553
Uniprot IDs		P33897	A0A0C4DGX8 A0A384MQW4 Q15904
PDB IDs
Enriched GO Terms of Interacting Partners?
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